======= RUNX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RUNX1
  * **<color #00a2e8>Official Name</color>**: RUNX family transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=861|861]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01196|Q01196]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RUNX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RUNX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151385|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RunxI|
|Runt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|core-binding factor complex|
|positive regulation of CD8-positive, alpha-beta T cell differentiation|
|regulation of CD8-positive, alpha-beta T cell differentiation|
|positive regulation of CD8-positive, alpha-beta T cell activation|
|positive regulation of granulocyte differentiation|
|peripheral nervous system neuron differentiation|
|peripheral nervous system neuron development|
|hematopoietic stem cell proliferation|
|regulation of granulocyte differentiation|
|regulation of CD8-positive, alpha-beta T cell activation|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of bicellular tight junction assembly|
|negative regulation of alpha-beta T cell differentiation|
|regulation of B cell receptor signaling pathway|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of regulatory T cell differentiation|
|positive regulation of interleukin-2 production|
|negative regulation of alpha-beta T cell activation|
|regulation of keratinocyte differentiation|
|regulation of intracellular estrogen receptor signaling pathway|
|negative regulation of T cell differentiation|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of lymphocyte differentiation|
|stem cell proliferation|
|regulation of megakaryocyte differentiation|
|regulation of interleukin-2 production|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of epidermal cell differentiation|
|regulation of alpha-beta T cell differentiation|
|regulation of antigen receptor-mediated signaling pathway|
|regulation of hematopoietic stem cell differentiation|
|peripheral nervous system development|
|regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of T cell differentiation|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of epidermis development|
|regulation of cell junction assembly|
|positive regulation of myeloid cell differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|negative regulation of leukocyte differentiation|
|negative regulation of T cell activation|
|regulation of myeloid leukocyte differentiation|
|regulation of stem cell differentiation|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|regulation of epithelial cell differentiation|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of angiogenesis|
|regulation of lymphocyte differentiation|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of response to cytokine stimulus|
|positive regulation of vasculature development|
|positive regulation of hemopoiesis|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|transcription regulatory region DNA binding|
|regulation of myeloid cell differentiation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|regulation of angiogenesis|
|regulation of leukocyte cell-cell adhesion|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of T cell activation|
|regulation of vasculature development|
|positive regulation of lymphocyte activation|
|regulation of Wnt signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of lymphocyte activation|
|cell population proliferation|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of cell activation|
|immune system development|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|neuron development|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of developmental process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.17|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.8|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.74|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.72|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.72|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.7|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.73|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.77|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.98|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.02|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.05|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.14|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.23|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.24|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.27|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.63|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.645|
|[[:human genes:c:cbfb|CBFB]]|0.639|
|[[:human genes:i:id3|ID3]]|0.595|
|[[:human genes:n:nsd1|NSD1]]|0.532|
|[[:human genes:s:ssbp2|SSBP2]]|0.514|
|[[:human genes:t:trim33|TRIM33]]|0.487|
|[[:human genes:b:bap1|BAP1]]|0.483|
|[[:human genes:m:maml1|MAML1]]|0.482|
|[[:human genes:z:zfx|ZFX]]|0.459|
|[[:human genes:w:wdr24|WDR24]]|0.451|
|[[:human genes:m:mlst8|MLST8]]|0.439|
|[[:human genes:l:ldb1|LDB1]]|0.432|
|[[:human genes:u:ube3a|UBE3A]]|0.431|
|[[:human genes:s:scaf8|SCAF8]]|0.43|
|[[:human genes:h:helz|HELZ]]|0.427|
|[[:human genes:r:rptor|RPTOR]]|0.421|
|[[:human genes:t:tada2b|TADA2B]]|0.419|
|[[:human genes:z:znf592|ZNF592]]|0.419|
|[[:human genes:z:zmym2|ZMYM2]]|0.417|
|[[:human genes:b:brpf1|BRPF1]]|0.416|
|[[:human genes:c:ccdc101|CCDC101]]|0.414|
|[[:human genes:d:dohh|DOHH]]|0.411|
|[[:human genes:z:zbtb44|ZBTB44]]|0.41|
|[[:human genes:s:sox7|SOX7]]|0.409|
|[[:human genes:s:smarcd1|SMARCD1]]|0.408|
|[[:human genes:s:setd1b|SETD1B]]|0.405|
|[[:human genes:i:id4|ID4]]|0.405|
|[[:human genes:p:papola|PAPOLA]]|0.403|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.403|
|[[:human genes:z:znf706|ZNF706]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|4/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 332
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RUNX1 Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>