======= RUSC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RUSC1
  * **<color #00a2e8>Official Name</color>**: RUN and SH3 domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23623|23623]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVN2|Q9BVN2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=RUSC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20RUSC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617318|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. {ECO:0000269|PubMed:19365808}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|SH3 2|
|RUN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SH3/SH2 adaptor activity|
|microtubule cytoskeleton|
|postsynaptic membrane|
|postsynaptic density|
|cytoplasmic vesicle|
|early endosome|
|actin binding|
|protein polyubiquitination|
|microtubule|
|cell junction|
|protein ubiquitination|
|protein modification by small protein conjugation|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|1.74|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.75|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.78|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.91|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.39|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3891
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='RUSC1 Expression in NALM6 Cells: 4.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>