======= S100A10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: S100A10
  * **<color #00a2e8>Official Name</color>**: S100 calcium binding protein A10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6281|6281]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60903|P60903]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=S100A10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20S100A10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114085|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|S 100|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|membrane raft assembly|
|membrane raft organization|
|positive regulation of focal adhesion assembly|
|extrinsic component of plasma membrane|
|positive regulation of adherens junction organization|
|protein heterotetramerization|
|positive regulation of cell junction assembly|
|membrane assembly|
|positive regulation of substrate adhesion-dependent cell spreading|
|membrane biogenesis|
|positive regulation of cell-matrix adhesion|
|positive regulation of stress fiber assembly|
|regulation of substrate adhesion-dependent cell spreading|
|regulation of focal adhesion assembly|
|regulation of cell-substrate junction assembly|
|positive regulation of actin filament bundle assembly|
|regulation of adherens junction organization|
|regulation of stress fiber assembly|
|regulation of actomyosin structure organization|
|regulation of cell junction assembly|
|regulation of actin filament bundle assembly|
|vesicle budding from membrane|
|protein heterooligomerization|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|ion channel binding|
|protein tetramerization|
|lipid binding|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of binding|
|protein localization to plasma membrane|
|positive regulation of supramolecular fiber organization|
|regulation of cell-substrate adhesion|
|positive regulation of cytoskeleton organization|
|membrane raft|
|protein localization to cell periphery|
|regulation of actin filament organization|
|vesicle organization|
|regulation of cell morphogenesis involved in differentiation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|collagen-containing extracellular matrix|
|regulation of binding|
|regulation of actin filament-based process|
|positive regulation of cell adhesion|
|positive regulation of GTPase activity|
|protein localization to membrane|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of organelle organization|
|regulation of cell adhesion|
|calcium ion binding|
|positive regulation of hydrolase activity|
|membrane organization|
|protein homodimerization activity|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|endoplasmic reticulum|
|response to drug|
|regulation of anatomical structure morphogenesis|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of molecular function|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.79|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.72|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.82|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.84|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.86|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.99|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13037
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='S100A10 Expression in NALM6 Cells: 2.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>