======= S100A14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: S100A14
  * **<color #00a2e8>Official Name</color>**: S100 calcium binding protein A14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57402|57402]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCY8|Q9HCY8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=S100A14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20S100A14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607986|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. {ECO:0000269|PubMed:21559403, ECO:0000269|PubMed:22032898, ECO:0000269|PubMed:22451655}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|S 100|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chemokine receptor binding|
|positive regulation of monocyte chemotaxis|
|toll-like receptor 4 signaling pathway|
|positive regulation of mononuclear cell migration|
|regulation of monocyte chemotaxis|
|positive regulation of granulocyte chemotaxis|
|regulation of granulocyte chemotaxis|
|regulation of mononuclear cell migration|
|positive regulation of leukocyte chemotaxis|
|toll-like receptor signaling pathway|
|regulation of leukocyte chemotaxis|
|pattern recognition receptor signaling pathway|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|nuclear body|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|defense response to bacterium|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|calcium ion homeostasis|
|regulation of innate immune response|
|positive regulation of defense response|
|divalent inorganic cation homeostasis|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|positive regulation of cellular component movement|
|cell junction|
|positive regulation of locomotion|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|activation of immune response|
|response to bacterium|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of defense response|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of cell motility|
|apoptotic process|
|defense response to other organism|
|regulation of locomotion|
|regulation of cellular component movement|
|programmed cell death|
|cell death|
|regulation of response to external stimulus|
|chemical homeostasis|
|regulation of immune response|
|positive regulation of immune system process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|response to oxygen-containing compound|
|homeostatic process|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6308
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='S100A14 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>