======= S1PR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: S1PR1
  * **<color #00a2e8>Official Name</color>**: sphingosine-1-phosphate receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1901|1901]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21453|P21453]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=S1PR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20S1PR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601974|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3- phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. {ECO:0000250, ECO:0000269|PubMed:10982820, ECO:0000269|PubMed:11230698, ECO:0000269|PubMed:11583630, ECO:0000269|PubMed:11604399, ECO:0000269|PubMed:19286607, ECO:0000269|PubMed:22344443, ECO:0000269|PubMed:8626678, ECO:0000269|PubMed:9488656}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cardiac muscle tissue growth involved in heart morphogenesis|
|sphingolipid binding|
|growth involved in heart morphogenesis|
|blood vessel maturation|
|sphingosine-1-phosphate receptor activity|
|sphingosine-1-phosphate receptor signaling pathway|
|sphingolipid mediated signaling pathway|
|negative regulation of stress fiber assembly|
|negative regulation of actin filament bundle assembly|
|positive regulation of positive chemotaxis|
|regulation of positive chemotaxis|
|T cell migration|
|cardiac muscle tissue growth|
|heart growth|
|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway|
|heart trabecula morphogenesis|
|lamellipodium assembly|
|intrinsic component of plasma membrane|
|regulation of bone resorption|
|lamellipodium organization|
|trabecula morphogenesis|
|regulation of bone remodeling|
|transmission of nerve impulse|
|actin cytoskeleton reorganization|
|G protein-coupled receptor binding|
|lymphocyte migration|
|cardiac muscle tissue morphogenesis|
|regulation of tissue remodeling|
|regulation of bone mineralization|
|regulation of stress fiber assembly|
|muscle tissue morphogenesis|
|endothelial cell differentiation|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|positive regulation of smooth muscle cell proliferation|
|muscle organ morphogenesis|
|regulation of actomyosin structure organization|
|regulation of biomineral tissue development|
|regulation of biomineralization|
|regulation of actin filament bundle assembly|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|endothelium development|
|organ growth|
|developmental growth involved in morphogenesis|
|negative regulation of supramolecular fiber organization|
|regulation of smooth muscle cell proliferation|
|multicellular organismal signaling|
|anatomical structure maturation|
|positive regulation of chemotaxis|
|negative regulation of cytoskeleton organization|
|leukocyte chemotaxis|
|cardiac muscle tissue development|
|regulation of ossification|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cell chemotaxis|
|regulation of chemotaxis|
|membrane raft|
|developmental maturation|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|heart morphogenesis|
|regulation of actin filament organization|
|endosome|
|positive regulation of cytosolic calcium ion concentration|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|angiogenesis|
|regulation of cytosolic calcium ion concentration|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|leukocyte migration|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|external side of plasma membrane|
|blood vessel morphogenesis|
|positive regulation of GTPase activity|
|cellular calcium ion homeostasis|
|plasma membrane bounded cell projection assembly|
|calcium ion homeostasis|
|cell projection assembly|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|regulation of GTPase activity|
|blood vessel development|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cellular metal ion homeostasis|
|tissue morphogenesis|
|actin filament-based process|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|regulation of cell adhesion|
|intracellular membrane-bounded organelle|
|negative regulation of cellular component organization|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|brain development|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|head development|
|ion homeostasis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|chemical homeostasis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|positive regulation of catalytic activity|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.512|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12259
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='S1PR1 Expression in NALM6 Cells: 2.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>