======= SAR1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SAR1B
  * **<color #00a2e8>Official Name</color>**: secretion associated Ras related GTPase 1B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51128|51128]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6B6|Q9Y6B6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SAR1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SAR1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a small GTPase that acts as a homodimer. The encoded protein is activated by the guanine nucleotide exchange factor PREB and is involved in protein transport from the endoplasmic reticulum to the Golgi. This protein is part of the COPII coat complex. Defects in this gene are a cause of chylomicron retention disease (CMRD), also known as Anderson disease (ANDD). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|G-alpha|
|Ras|
|SRPRB|
|Arf|
|Miro|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis|
|regulation of COPII vesicle coating|
|regulation of vesicle targeting, to, from or within Golgi|
|positive regulation of protein exit from endoplasmic reticulum|
|COPII vesicle coat|
|regulation of ER to Golgi vesicle-mediated transport|
|regulation of protein exit from endoplasmic reticulum|
|endoplasmic reticulum exit site|
|ER to Golgi transport vesicle membrane|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|vesicle targeting|
|Golgi cisterna membrane|
|vesicle budding from membrane|
|antigen processing and presentation of peptide antigen via MHC class I|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|positive regulation of intracellular protein transport|
|establishment of vesicle localization|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|positive regulation of intracellular transport|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|regulation of intracellular protein transport|
|vesicle organization|
|positive regulation of cellular protein localization|
|GTPase activity|
|regulation of intracellular transport|
|establishment of organelle localization|
|Golgi vesicle transport|
|GTP binding|
|positive regulation of protein transport|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|organelle localization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|membrane organization|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|intracellular protein transport|
|endoplasmic reticulum|
|regulation of protein localization|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.479|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17916
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SAR1B Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>