======= SCAF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCAF1
  * **<color #00a2e8>Official Name</color>**: SR-related CTD associated factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58506|58506]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7N4|Q9H7N4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCAF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCAF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617264|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function in pre-mRNA splicing. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II C-terminal domain binding|
|protein domain specific binding|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-3.2|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.72|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.65|
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.14|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.93|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.85|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.72|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|1.71|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|1.73|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.8|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.8|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.84|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.84|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.85|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.87|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.95|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.96|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.99|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.19|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|2.4|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|2.55|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.55|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.66|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.79|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.82|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmd1|PSMD1]]|0.534|
|[[:human genes:v:vasn|VASN]]|0.531|
|[[:human genes:p:psmd11|PSMD11]]|0.519|
|[[:human genes:p:pcf11|PCF11]]|0.519|
|[[:human genes:r:rps2|RPS2]]|0.516|
|[[:human genes:z:zfand5|ZFAND5]]|0.512|
|[[:human genes:n:nop16|NOP16]]|0.501|
|[[:human genes:m:myo1h|MYO1H]]|0.5|
|[[:human genes:r:rps28|RPS28]]|0.487|
|[[:human genes:s:smg7|SMG7]]|0.481|
|[[:human genes:u:upf1|UPF1]]|0.478|
|[[:human genes:s:smg1|SMG1]]|0.477|
|[[:human genes:m:mt1e|MT1E]]|0.474|
|[[:human genes:c:chmp2a|CHMP2A]]|0.474|
|[[:human genes:p:prpf8|PRPF8]]|0.473|
|[[:human genes:s:supt6h|SUPT6H]]|0.47|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.469|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.466|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.465|
|[[:human genes:t:top1mt|TOP1MT]]|0.465|
|[[:human genes:r:rpsa|RPSA]]|0.464|
|[[:human genes:s:s1pr4|S1PR4]]|0.463|
|[[:human genes:c:cdc73|CDC73]]|0.463|
|[[:human genes:p:pan3|PAN3]]|0.462|
|[[:human genes:t:twistnb|TWISTNB]]|0.462|
|[[:human genes:n:nupl1|NUPL1]]|0.462|
|[[:human genes:r:rps12|RPS12]]|0.462|
|[[:human genes:t:terf1|TERF1]]|0.456|
|[[:human genes:t:tceb3c|TCEB3C]]|0.455|
|[[:human genes:r:rad21|RAD21]]|0.453|
|[[:human genes:h:hmgcr|HMGCR]]|0.452|
|[[:human genes:p:psma7|PSMA7]]|0.451|
|[[:human genes:o:orc1|ORC1]]|0.451|
|[[:human genes:g:gar1|GAR1]]|0.45|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.449|
|[[:human genes:p:psmb4|PSMB4]]|0.448|
|[[:human genes:s:sfpq|SFPQ]]|0.446|
|[[:human genes:p:psmd13|PSMD13]]|0.445|
|[[:human genes:p:prim1|PRIM1]]|0.441|
|[[:human genes:m:med29|MED29]]|0.441|
|[[:human genes:p:psma6|PSMA6]]|0.44|
|[[:human genes:s:srgap2c|SRGAP2C]]|0.438|
|[[:human genes:r:rbm39|RBM39]]|0.437|
|[[:human genes:h:hap1|HAP1]]|0.437|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.436|
|[[:human genes:r:rps11|RPS11]]|0.436|
|[[:human genes:s:syt9|SYT9]]|0.435|
|[[:human genes:p:psmc6|PSMC6]]|0.435|
|[[:human genes:c:cbwd3|CBWD3]]|0.435|
|[[:human genes:p:psmb1|PSMB1]]|0.434|
|[[:human genes:f:fbxo5|FBXO5]]|0.434|
|[[:human genes:n:narfl|NARFL]]|0.434|
|[[:human genes:r:rnf4|RNF4]]|0.433|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.431|
|[[:human genes:i:igfn1|IGFN1]]|0.428|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.428|
|[[:human genes:m:mdm2|MDM2]]|0.426|
|[[:human genes:d:dtl|DTL]]|0.425|
|[[:human genes:c:cbwd5|CBWD5]]|0.425|
|[[:human genes:a:akirin2|AKIRIN2]]|0.424|
|[[:human genes:u:ubap1|UBAP1]]|0.424|
|[[:human genes:c:chd4|CHD4]]|0.423|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.422|
|[[:human genes:s:slc38a7|SLC38A7]]|0.422|
|[[:human genes:r:rps9|RPS9]]|0.422|
|[[:human genes:d:ddtl|DDTL]]|0.421|
|[[:human genes:e:elmod3|ELMOD3]]|0.42|
|[[:human genes:n:nup54|NUP54]]|0.419|
|[[:human genes:z:znf106|ZNF106]]|0.419|
|[[:human genes:n:npipb8|NPIPB8]]|0.419|
|[[:human genes:p:pan2|PAN2]]|0.419|
|[[:human genes:s:sf3a1|SF3A1]]|0.419|
|[[:human genes:a:aqr|AQR]]|0.417|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.417|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.417|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.417|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.417|
|[[:human genes:c:copz1|COPZ1]]|0.417|
|[[:human genes:n:nbpf10|NBPF10]]|0.416|
|[[:human genes:s:ssh2|SSH2]]|0.416|
|[[:human genes:c:cope|COPE]]|0.415|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.415|
|[[:human genes:e:exosc5|EXOSC5]]|0.414|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.414|
|[[:human genes:c:c14orf93|C14orf93]]|0.414|
|[[:human genes:d:dido1|DIDO1]]|0.413|
|[[:human genes:n:npipb5|NPIPB5]]|0.413|
|[[:human genes:n:nip7|NIP7]]|0.412|
|[[:human genes:s:smg5|SMG5]]|0.411|
|[[:human genes:p:paf1|PAF1]]|0.41|
|[[:human genes:p:plk1|PLK1]]|0.409|
|[[:human genes:d:dnm2|DNM2]]|0.409|
|[[:human genes:n:nup153|NUP153]]|0.407|
|[[:human genes:t:traip|TRAIP]]|0.407|
|[[:human genes:p:psmc2|PSMC2]]|0.407|
|[[:human genes:a:ankle1|ANKLE1]]|0.407|
|[[:human genes:r:rps14|RPS14]]|0.406|
|[[:human genes:b:bad|BAD]]|0.405|
|[[:human genes:p:pola2|POLA2]]|0.404|
|[[:human genes:k:krt78|KRT78]]|0.404|
|[[:human genes:a:atxn1|ATXN1]]|0.403|
|[[:human genes:c:copg1|COPG1]]|0.403|
|[[:human genes:c:cdt1|CDT1]]|0.402|
|[[:human genes:m:med17|MED17]]|0.402|
|[[:human genes:p:ppfia4|PPFIA4]]|0.402|
|[[:human genes:k:kctd17|KCTD17]]|0.402|
|[[:human genes:c:ctr9|CTR9]]|0.402|
|[[:human genes:o:ogfr|OGFR]]|0.401|
|[[:human genes:p:psmd14|PSMD14]]|0.401|
|[[:human genes:r:rad51|RAD51]]|0.401|
|[[:human genes:n:nup107|NUP107]]|0.4|
|[[:human genes:d:ddx56|DDX56]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 337
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCAF1 Expression in NALM6 Cells: 6.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>