======= SCARB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCARB2
  * **<color #00a2e8>Official Name</color>**: scavenger receptor class B member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=950|950]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14108|Q14108]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCARB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCARB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602257|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. {ECO:0000269|PubMed:18022370}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CD36|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of glucosylceramidase activity|
|regulation of endosome organization|
|regulation of lysosome organization|
|aminophospholipid transport|
|regulation of cellular carbohydrate catabolic process|
|cargo receptor activity|
|phospholipid transporter activity|
|protein targeting to lysosome|
|phosphatidylcholine binding|
|protein targeting to vacuole|
|protein localization to lysosome|
|regulation of vacuole organization|
|establishment of protein localization to vacuole|
|cholesterol binding|
|scavenger receptor activity|
|clathrin-coated vesicle membrane|
|phosphatidylserine binding|
|protein localization to vacuole|
|endocytic vesicle membrane|
|virus receptor activity|
|regulation of carbohydrate catabolic process|
|phospholipid transport|
|lysosomal lumen|
|viral entry into host cell|
|chaperone binding|
|entry into host|
|entry into host cell|
|lysosomal transport|
|late endosome membrane|
|organophosphate ester transport|
|transmembrane signaling receptor activity|
|regulation of cellular carbohydrate metabolic process|
|vacuolar transport|
|interaction with host|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|endosome membrane|
|receptor-mediated endocytosis|
|positive regulation of neuron projection development|
|lipid transport|
|lysosomal membrane|
|lipid localization|
|enzyme binding|
|protein targeting|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|focal adhesion|
|establishment of protein localization to organelle|
|organic anion transport|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|endocytosis|
|anion transport|
|Golgi membrane|
|regulation of neuron differentiation|
|import into cell|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulation of cell projection organization|
|protein localization to organelle|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|positive regulation of cell differentiation|
|intracellular protein transport|
|regulation of catabolic process|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|positive regulation of developmental process|
|ion transport|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.9|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.88|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.78|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.76|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.81|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14080
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCARB2 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>