======= SCIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCIN
  * **<color #00a2e8>Official Name</color>**: scinderin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85477|85477]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6U3|Q9Y6U3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613416|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009). {ECO:0000250|UniProtKB:Q28046, ECO:0000250|UniProtKB:Q5ZIV9, ECO:0000250|UniProtKB:Q60604, ECO:0000269|PubMed:11568009, ECO:0000269|PubMed:26365202, ECO:0000269|PubMed:8547642}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gelsolin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of megakaryocyte differentiation|
|actin filament severing|
|sequestering of actin monomers|
|positive regulation of actin nucleation|
|1-phosphatidylinositol binding|
|regulation of actin nucleation|
|podosome|
|actin nucleation|
|actin filament capping|
|negative regulation of actin filament depolymerization|
|calcium-ion regulated exocytosis|
|brush border|
|regulation of actin filament depolymerization|
|regulation of chondrocyte differentiation|
|negative regulation of actin filament polymerization|
|regulation of megakaryocyte differentiation|
|phosphatidylserine binding|
|negative regulation of protein depolymerization|
|negative regulation of protein polymerization|
|regulation of cartilage development|
|negative regulation of protein complex disassembly|
|maintenance of protein location in cell|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of protein depolymerization|
|positive regulation of actin filament polymerization|
|positive regulation of myeloid cell differentiation|
|maintenance of location in cell|
|cell projection|
|maintenance of protein location|
|regulation of protein complex disassembly|
|positive regulation of protein polymerization|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|cell cortex|
|negative regulation of cytoskeleton organization|
|maintenance of location|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|positive regulation of hemopoiesis|
|positive regulation of supramolecular fiber organization|
|actin filament binding|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|regulation of myeloid cell differentiation|
|actin filament organization|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|actin binding|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|positive regulation of secretion|
|regulation of hemopoiesis|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|cell junction|
|actin filament-based process|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulated exocytosis|
|negative regulation of cellular component organization|
|calcium ion binding|
|exocytosis|
|regulation of secretion|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|cytoskeleton organization|
|secretion|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.8|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.31|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.75|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.9|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.92|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.18|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|3.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17400
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCIN Expression in NALM6 Cells: 3.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>