======= SCO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SCO1
  * **<color #00a2e8>Official Name</color>**: synthesis of cytochrome C oxidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6341|6341]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75880|O75880]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SCO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SCO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603644|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of MT-CO2/COX2. {ECO:0000269|PubMed:15659396, ECO:0000269|PubMed:16735468, ECO:0000269|PubMed:17189203}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SCO1-SenC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|host cell mitochondrial intermembrane space|
|cellular copper ion homeostasis|
|copper ion transport|
|copper ion homeostasis|
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|myofibril|
|cytochrome complex assembly|
|integral component of mitochondrial inner membrane|
|copper ion binding|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of cellular protein catabolic process|
|mitochondrial respiratory chain complex assembly|
|cellular transition metal ion homeostasis|
|transition metal ion transport|
|transition metal ion homeostasis|
|negative regulation of protein catabolic process|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|mitochondrial inner membrane|
|mitochondrion organization|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of proteolysis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|mitochondrion|
|ion transport|
|protein-containing complex assembly|
|homeostatic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.81|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.75|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.86|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.18|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.2|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pet117|PET117]]|0.5|
|[[:human genes:s:selrc1|SELRC1]]|0.471|
|[[:human genes:c:coa3|COA3]]|0.471|
|[[:human genes:g:gfm2|GFM2]]|0.468|
|[[:human genes:l:lars2|LARS2]]|0.453|
|[[:human genes:m:mrps27|MRPS27]]|0.45|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.448|
|[[:human genes:c:cox16|COX16]]|0.443|
|[[:human genes:t:tfb1m|TFB1M]]|0.443|
|[[:human genes:m:mrps26|MRPS26]]|0.442|
|[[:human genes:m:mettl17|METTL17]]|0.442|
|[[:human genes:q:qrsl1|QRSL1]]|0.436|
|[[:human genes:a:aifm1|AIFM1]]|0.436|
|[[:human genes:n:nars2|NARS2]]|0.434|
|[[:human genes:m:mrp63|MRP63]]|0.433|
|[[:human genes:m:mrpl45|MRPL45]]|0.431|
|[[:human genes:s:sco2|SCO2]]|0.431|
|[[:human genes:m:mrps16|MRPS16]]|0.427|
|[[:human genes:m:mrps25|MRPS25]]|0.427|
|[[:human genes:d:dars2|DARS2]]|0.423|
|[[:human genes:c:cox19|COX19]]|0.423|
|[[:human genes:m:mrps6|MRPS6]]|0.423|
|[[:human genes:m:mrpl53|MRPL53]]|0.422|
|[[:human genes:c:coa6|COA6]]|0.421|
|[[:human genes:p:pet112|PET112]]|0.419|
|[[:human genes:c:cox11|COX11]]|0.41|
|[[:human genes:h:hars2|HARS2]]|0.409|
|[[:human genes:g:gfm1|GFM1]]|0.408|
|[[:human genes:a:aars2|AARS2]]|0.407|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2431
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SCO1 Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>