======= SEC14L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC14L1
  * **<color #00a2e8>Official Name</color>**: SEC14 like lipid binding 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6397|6397]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92503|Q92503]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC14L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC14L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601504|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608). {ECO:0000269|PubMed:17092608, ECO:0000269|PubMed:23843640}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PRELI|
|CRAL TRIO|
|CRAL TRIO N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RIG-I binding|
|molecular function regulator|
|choline transport|
|negative regulation of RIG-I signaling pathway|
|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|regulation of RIG-I signaling pathway|
|regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|
|negative regulation of defense response to virus|
|organic cation transport|
|ammonium transport|
|regulation of defense response to virus|
|negative regulation of response to biotic stimulus|
|negative regulation of immune effector process|
|neurotransmitter transport|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|negative regulation of response to external stimulus|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of immune effector process|
|negative regulation of intracellular signal transduction|
|regulation of response to biotic stimulus|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|cation transport|
|defense response to other organism|
|Golgi apparatus|
|regulation of response to external stimulus|
|regulation of immune response|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.97|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.21|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.15|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.86|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.84|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.98|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|2.04|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.16|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.23|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.41|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11893
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC14L1 Expression in NALM6 Cells: 5.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>