======= SEMA3C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA3C
  * **<color #00a2e8>Official Name</color>**: semaphorin 3C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10512|10512]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99985|Q99985]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA3C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA3C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602645|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sema|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cardiac endothelial to mesenchymal transition|
|pulmonary myocardium development|
|positive regulation of neural crest cell differentiation|
|positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|
|regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis|
|regulation of neural crest cell differentiation|
|dichotomous subdivision of terminal units involved in salivary gland branching|
|dichotomous subdivision of an epithelial terminal unit|
|limb bud formation|
|venous blood vessel development|
|branching involved in salivary gland morphogenesis|
|neuropilin binding|
|cardiac right ventricle morphogenesis|
|positive regulation of stem cell differentiation|
|semaphorin receptor binding|
|negative regulation of axon extension involved in axon guidance|
|chemorepellent activity|
|outflow tract septum morphogenesis|
|negative regulation of axon guidance|
|positive regulation of cardiocyte differentiation|
|salivary gland morphogenesis|
|regulation of axon extension involved in axon guidance|
|blood vessel remodeling|
|salivary gland development|
|semaphorin-plexin signaling pathway|
|regulation of heart morphogenesis|
|negative regulation of axon extension|
|exocrine system development|
|regulation of axon guidance|
|negative chemotaxis|
|regulation of cardiocyte differentiation|
|neural crest cell migration|
|negative regulation of chemotaxis|
|somitogenesis|
|negative regulation of axonogenesis|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|cardiac ventricle morphogenesis|
|neural crest cell development|
|positive regulation of animal organ morphogenesis|
|somite development|
|mesenchymal cell development|
|stem cell development|
|post-embryonic development|
|neural crest cell differentiation|
|segmentation|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|gland morphogenesis|
|tissue remodeling|
|negative regulation of developmental growth|
|cardiac septum development|
|regulation of extent of cell growth|
|regulation of stem cell differentiation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|limb morphogenesis|
|appendage morphogenesis|
|negative regulation of neuron projection development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|neural tube development|
|morphogenesis of a branching structure|
|cardiac chamber development|
|ameboidal-type cell migration|
|limb development|
|appendage development|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|regulation of chemotaxis|
|anterior/posterior pattern specification|
|mesenchyme development|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|axon guidance|
|neuron projection guidance|
|striated muscle tissue development|
|negative regulation of neurogenesis|
|muscle tissue development|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|regionalization|
|negative regulation of cell development|
|negative regulation of response to external stimulus|
|axonogenesis|
|regulation of cellular component size|
|axon development|
|gland development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|vasculature development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|response to drug|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10467
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA3C Expression in NALM6 Cells: -2.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>