======= SEMA3E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA3E
  * **<color #00a2e8>Official Name</color>**: semaphorin 3E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9723|9723]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15041|O15041]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA3E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA3E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608166|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down- regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
|Sema|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuropilin binding|
|semaphorin receptor binding|
|negative regulation of axon extension involved in axon guidance|
|chemorepellent activity|
|branching involved in blood vessel morphogenesis|
|negative regulation of axon guidance|
|regulation of axon extension involved in axon guidance|
|semaphorin-plexin signaling pathway|
|regulation of actin cytoskeleton reorganization|
|negative regulation of cell-matrix adhesion|
|negative regulation of axon extension|
|regulation of axon guidance|
|negative chemotaxis|
|neural crest cell migration|
|negative regulation of chemotaxis|
|sprouting angiogenesis|
|negative regulation of cell-substrate adhesion|
|negative regulation of axonogenesis|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|neural crest cell differentiation|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of angiogenesis|
|negative regulation of developmental growth|
|negative regulation of blood vessel morphogenesis|
|regulation of extent of cell growth|
|regulation of cell-matrix adhesion|
|negative regulation of vasculature development|
|branching morphogenesis of an epithelial tube|
|regulation of cell shape|
|negative regulation of neuron projection development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|ameboidal-type cell migration|
|regulation of cell size|
|negative regulation of cell projection organization|
|negative regulation of cell growth|
|regulation of axonogenesis|
|regulation of cell-substrate adhesion|
|regulation of chemotaxis|
|mesenchyme development|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|synapse organization|
|negative regulation of cell adhesion|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of actin cytoskeleton organization|
|negative regulation of response to external stimulus|
|regulation of cellular component size|
|regulation of actin filament-based process|
|blood vessel morphogenesis|
|regulation of cell growth|
|morphogenesis of an epithelium|
|blood vessel development|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|tissue morphogenesis|
|tube morphogenesis|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|epithelium development|
|negative regulation of multicellular organismal process|
|regulation of organelle organization|
|locomotion|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|tissue development|
|regulation of cell differentiation|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13518
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA3E Expression in NALM6 Cells: 0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>