======= SENP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SENP6
  * **<color #00a2e8>Official Name</color>**: SUMO specific peptidase 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26054|26054]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZR1|Q9GZR1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SENP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SENP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605003|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination. {ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875, ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317, ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C48|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SUMO-specific endopeptidase activity|
|regulation of kinetochore assembly|
|regulation of centromere complex assembly|
|protein desumoylation|
|regulation of spindle assembly|
|regulation of spindle organization|
|protein sumoylation|
|regulation of microtubule cytoskeleton organization|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|protein modification by small protein removal|
|peptidyl-lysine modification|
|regulation of chromosome organization|
|regulation of protein complex assembly|
|regulation of cytoskeleton organization|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|peptidyl-amino acid modification|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|regulation of cell cycle|
|proteolysis|
|regulation of organelle organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.39|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.99|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.86|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.78|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.73|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 590/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|19/28|
|bone|22/25|
|breast|24/33|
|central nervous system|44/56|
|cervix|3/4|
|colorectal|14/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|11/15|
|kidney|18/21|
|liver|15/20|
|lung|62/75|
|lymphocyte|9/14|
|ovary|25/26|
|pancreas|20/24|
|peripheral nervous system|12/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|5/7|
|thyroid|1/2|
|upper aerodigestive|16/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3894
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SENP6 Expression in NALM6 Cells: 6.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>