======= SEPHS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEPHS1
  * **<color #00a2e8>Official Name</color>**: selenophosphate synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22929|22929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49903|P49903]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEPHS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEPHS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600902|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Synthesizes selenophosphate from selenide and ATP. {ECO:0000269|PubMed:7665581}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AIRS C|
|AIRS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA seleno-modification|
|selenocysteine biosynthetic process|
|selenide, water dikinase activity|
|selenocysteine metabolic process|
|selenium compound metabolic process|
|serine family amino acid biosynthetic process|
|serine family amino acid metabolic process|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|alpha-amino acid metabolic process|
|nuclear membrane|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|ncRNA processing|
|GTP binding|
|ncRNA metabolic process|
|small molecule biosynthetic process|
|RNA processing|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|identical protein binding|
|phosphorylation|
|organonitrogen compound biosynthetic process|
|ATP binding|
|RNA metabolic process|
|small molecule metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.91|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-3.86|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.69|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-3.59|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-3.58|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-3.56|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-3.55|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-3.48|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-3.28|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-3.2|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-3.19|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-3.16|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-3.13|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-3.04|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-3.01|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.95|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.9|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.89|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.87|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.76|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.76|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.75|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.74|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.72|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.7|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.64|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.63|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-2.59|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.59|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.47|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.46|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.44|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.39|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.33|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.31|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.31|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.31|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.3|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-2.27|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.26|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.25|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-2.24|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.22|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.22|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.2|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.17|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.17|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.16|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.15|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.15|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.14|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-2.12|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.09|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.07|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-2.04|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.02|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.98|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.96|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.95|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.94|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.94|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.89|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.89|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.88|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-1.88|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.84|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.84|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.83|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.82|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.82|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-1.8|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.8|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.79|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.79|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.78|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.76|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.75|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.72|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-1.72|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.71|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.7|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.7|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.7|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.7|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.71|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.72|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.91|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.97|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.11|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.26|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:q:qrich1|QRICH1]]|0.651|
|[[:human genes:t:tacc3|TACC3]]|0.501|
|[[:human genes:d:dlgap5|DLGAP5]]|0.468|
|[[:human genes:a:aspm|ASPM]]|0.436|
|[[:human genes:c:calm2|CALM2]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17493
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEPHS1 Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>