======= SERAC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERAC1
  * **<color #00a2e8>Official Name</color>**: serine active site containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84947|84947]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JX3|Q96JX3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERAC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERAC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614725|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a phosphatidylglycerol remodeling protein found at the interface of mitochondria and endoplasmic reticula, where it mediates phospholipid exchange. The encoded protein plays a major role in mitochondrial function and intracellular cholesterol trafficking. Defects in this gene are a cause of 3-methylglutaconic aciduria with deafness, encephalopathy, and Leigh-like syndrome (MEGDEL). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway. {ECO:0000269|PubMed:22683713}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PGAP1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondria-associated endoplasmic reticulum membrane|
|intracellular cholesterol transport|
|intracellular sterol transport|
|phosphatidylglycerol acyl-chain remodeling|
|phosphatidylglycerol metabolic process|
|intracellular lipid transport|
|cholesterol transport|
|sterol transport|
|organic hydroxy compound transport|
|extracellular matrix|
|phospholipid biosynthetic process|
|lipid transport|
|glycerophospholipid metabolic process|
|lipid localization|
|extracellular matrix organization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|extracellular structure organization|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|molecular function|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|lipid metabolic process|
|mitochondrion|
|intracellular transport|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.7|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.78|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.82|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.85|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.89|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.92|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.93|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.12|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16808
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERAC1 Expression in NALM6 Cells: 4.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>