======= SERPINA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPINA3
  * **<color #00a2e8>Official Name</color>**: serpin family A member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=12|12]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01011|P01011]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPINA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPINA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of gastrointestinal epithelium|
|epithelial structure maintenance|
|acute-phase response|
|platelet alpha granule lumen|
|acute inflammatory response|
|digestive system process|
|azurophil granule lumen|
|serine-type endopeptidase inhibitor activity|
|digestion|
|secretory granule lumen|
|platelet degranulation|
|blood microparticle|
|tissue homeostasis|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|negative regulation of proteolysis|
|collagen-containing extracellular matrix|
|regulation of lipid metabolic process|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|regulation of proteolysis|
|leukocyte mediated immunity|
|negative regulation of catalytic activity|
|exocytosis|
|leukocyte activation|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|defense response|
|DNA binding|
|extracellular space|
|homeostatic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.82|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.76|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.74|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12466
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPINA3 Expression in NALM6 Cells: -1.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>