======= SESN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SESN1
  * **<color #00a2e8>Official Name</color>**: sestrin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27244|27244]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6P5|Q9Y6P5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SESN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SESN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606103|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:23274085, ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:26449471}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PA26|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peroxiredoxin activity|
|oxidoreductase activity, acting on peroxide as acceptor|
|leucine binding|
|cellular response to leucine starvation|
|cellular response to leucine|
|TORC2 complex|
|GATOR2 complex|
|response to leucine|
|negative regulation of TORC1 signaling|
|regulation of response to reactive oxygen species|
|regulation of TORC1 signaling|
|cellular response to glucose starvation|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|negative regulation of TOR signaling|
|positive regulation of macroautophagy|
|cellular response to amino acid stimulus|
|regulation of response to oxidative stress|
|cellular oxidant detoxification|
|cellular detoxification|
|regulation of TOR signaling|
|reactive oxygen species metabolic process|
|response to amino acid|
|positive regulation of autophagy|
|detoxification|
|fibrillar center|
|cellular response to starvation|
|regulation of macroautophagy|
|response to starvation|
|cellular response to acid chemical|
|cellular response to toxic substance|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|regulation of autophagy|
|cellular response to external stimulus|
|response to acid chemical|
|positive regulation of cellular catabolic process|
|positive regulation of catabolic process|
|response to nutrient levels|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|response to extracellular stimulus|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|regulation of cellular catabolic process|
|oxidation-reduction process|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|cellular response to stress|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.01|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-1.79|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.72|
|[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18919
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SESN1 Expression in NALM6 Cells: 3.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>