======= SFRP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SFRP4
  * **<color #00a2e8>Official Name</color>**: secreted frizzled related protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6424|6424]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6FHJ7|Q6FHJ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SFRP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SFRP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927). {ECO:0000250|UniProtKB:Q9JLS4, ECO:0000250|UniProtKB:Q9Z1N6, ECO:0000269|PubMed:12952927}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fz|
|NTR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of sodium-dependent phosphate transport|
|positive regulation of keratinocyte apoptotic process|
|regulation of sodium-dependent phosphate transport|
|regulation of keratinocyte apoptotic process|
|negative regulation of non-canonical Wnt signaling pathway|
|regulation of phosphate transport|
|divalent inorganic anion homeostasis|
|phosphate ion homeostasis|
|trivalent inorganic anion homeostasis|
|regulation of non-canonical Wnt signaling pathway|
|positive regulation of epidermal cell differentiation|
|positive regulation of receptor internalization|
|monovalent inorganic anion homeostasis|
|negative regulation of anion transport|
|positive regulation of epithelial cell apoptotic process|
|Wnt-protein binding|
|positive regulation of epidermis development|
|positive regulation of receptor-mediated endocytosis|
|regulation of receptor internalization|
|anion homeostasis|
|positive regulation of epithelial cell differentiation|
|regulation of epidermal cell differentiation|
|regulation of epithelial cell apoptotic process|
|regulation of epidermis development|
|regulation of BMP signaling pathway|
|canonical Wnt signaling pathway|
|regulation of anion transport|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|bone morphogenesis|
|non-canonical Wnt signaling pathway|
|regulation of epithelial cell differentiation|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of ion transport|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|bone development|
|regulation of endocytosis|
|negative regulation of Wnt signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|regulation of DNA-binding transcription factor activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|negative regulation of transport|
|skeletal system development|
|regulation of vesicle-mediated transport|
|cell surface|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|regulation of ion transport|
|inorganic ion homeostasis|
|ion homeostasis|
|response to hormone|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|positive regulation of transport|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|response to endogenous stimulus|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.72|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.71|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.73|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.77|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.79|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.02|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.28|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.52|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.62|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14998
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SFRP4 Expression in NALM6 Cells: -1.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>