======= SFTPD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SFTPD
  * **<color #00a2e8>Official Name</color>**: surfactant protein D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6441|6441]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35247|P35247]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SFTPD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SFTPD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/178635|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. {ECO:0000269|PubMed:23478426}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
|Collagen|
|Surfac D-trimer|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of adhesion of symbiont to host epithelial cell|
|negative regulation of interleukin-2 biosynthetic process|
|negative regulation by host of symbiont molecular function|
|induction of bacterial agglutination|
|modulation by host of symbiont molecular function|
|negative regulation of molecular function in other organism|
|negative regulation of molecular function in other organism involved in symbiotic interaction|
|modulation of molecular function in other organism|
|modulation of molecular function in other organism involved in symbiotic interaction|
|surfactant homeostasis|
|chemical homeostasis within a tissue|
|macrophage chemotaxis|
|monosaccharide binding|
|regulation of interleukin-2 biosynthetic process|
|macrophage migration|
|negative regulation of interleukin-2 production|
|clathrin-coated endocytic vesicle|
|negative regulation of cytokine biosynthetic process|
|multivesicular body|
|lipopolysaccharide binding|
|antibacterial humoral response|
|lung alveolus development|
|respiratory gaseous exchange by respiratory system|
|regulation of interleukin-2 production|
|endocytic vesicle|
|negative regulation of T cell proliferation|
|rough endoplasmic reticulum|
|collagen trimer|
|positive regulation of phagocytosis|
|modification by host of symbiont morphology or physiology|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|interaction with symbiont|
|negative regulation of leukocyte proliferation|
|regulation of phagocytosis|
|toll-like receptor signaling pathway|
|regulation of cytokine biosynthetic process|
|negative regulation of T cell activation|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|antimicrobial humoral response|
|reactive oxygen species metabolic process|
|negative regulation of leukocyte cell-cell adhesion|
|pattern recognition receptor signaling pathway|
|myeloid leukocyte migration|
|negative regulation of lymphocyte activation|
|leukocyte chemotaxis|
|modification of morphology or physiology of other organism|
|regulation of T cell proliferation|
|lung development|
|respiratory tube development|
|carbohydrate binding|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|tissue homeostasis|
|respiratory system development|
|negative regulation of cell activation|
|regulation of lymphocyte proliferation|
|cell chemotaxis|
|regulation of mononuclear cell proliferation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of leukocyte proliferation|
|innate immune response-activating signal transduction|
|receptor-mediated endocytosis|
|lysosome|
|activation of innate immune response|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|defense response to bacterium|
|positive regulation of innate immune response|
|anatomical structure homeostasis|
|humoral immune response|
|positive regulation of response to biotic stimulus|
|leukocyte migration|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|endocytosis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|activation of immune response|
|regulation of cell activation|
|import into cell|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|response to bacterium|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|tube development|
|positive regulation of immune response|
|endoplasmic reticulum membrane|
|defense response to other organism|
|cell migration|
|positive regulation of transport|
|identical protein binding|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|extracellular space|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4679
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SFTPD Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>