======= SGCD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGCD
  * **<color #00a2e8>Official Name</color>**: sarcoglycan delta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6444|6444]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92629|Q92629]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SGCD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SGCD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601411|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sarcoglycan 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sarcoglycan complex|
|coronary vasculature morphogenesis|
|dystrophin-associated glycoprotein complex|
|cardiac muscle fiber development|
|cellular protein-containing complex localization|
|cardiac muscle cell contraction|
|sarcoplasmic reticulum|
|coronary vasculature development|
|muscle fiber development|
|cardiac muscle cell development|
|cardiac cell development|
|cardiac muscle contraction|
|heart contraction|
|cardiac muscle cell differentiation|
|actin-mediated cell contraction|
|sarcolemma|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|cardiocyte differentiation|
|striated muscle cell development|
|calcium-mediated signaling|
|muscle cell development|
|cardiac muscle tissue development|
|striated muscle cell differentiation|
|muscle cell differentiation|
|muscle contraction|
|protein-containing complex localization|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|second-messenger-mediated signaling|
|cytoskeleton|
|blood circulation|
|circulatory system process|
|blood vessel morphogenesis|
|calcium ion homeostasis|
|muscle structure development|
|blood vessel development|
|divalent inorganic cation homeostasis|
|vasculature development|
|cardiovascular system development|
|heart development|
|actin filament-based process|
|metal ion homeostasis|
|tube morphogenesis|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|tube development|
|circulatory system development|
|cell death|
|chemical homeostasis|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16005
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SGCD Expression in NALM6 Cells: -2.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>