======= SH3TC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SH3TC2
  * **<color #00a2e8>Official Name</color>**: SH3 domain and tetratricopeptide repeats 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79628|79628]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TF17|Q8TF17]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SH3TC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SH3TC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608206|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with two N-terminal Src homology 3 (SH3) domains and 10 tetratricopeptide repeat (TPR) motifs, and is a member of a small gene family. The gene product has been proposed to be an adapter or docking molecule. Mutations in this gene result in autosomal recessive Charcot-Marie-Tooth disease type 4C, a childhood-onset neurodegenerative disease characterized by demyelination of motor and sensory neurons. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peripheral nervous system myelin maintenance|
|myelin maintenance|
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|Schwann cell development|
|Schwann cell differentiation|
|peripheral nervous system development|
|regulation of ERBB signaling pathway|
|plasma membrane organization|
|myelination|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|glial cell differentiation|
|gliogenesis|
|regulation of intracellular protein transport|
|cytoplasmic vesicle|
|regulation of intracellular transport|
|endomembrane system organization|
|regulation of cellular protein localization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|membrane organization|
|regulation of cellular localization|
|regulation of protein localization|
|neurogenesis|
|cell development|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.03|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.81|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7259
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SH3TC2 Expression in NALM6 Cells: 2.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>