======= SHH =======
== Gene Information ==
* **Official Symbol**: SHH
* **Official Name**: sonic hedgehog signaling molecule
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6469|6469]]
* **UniProt**: [[https://www.uniprot.org/uniprot/Q15465|Q15465]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=SHH&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHH|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/600725|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008].
* **UniProt Summary**: Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q62226}.
|HH signal|
|Hint|
|regulation of ureter smooth muscle cell differentiation|
|regulation of smooth muscle tissue development|
|positive regulation of kidney smooth muscle cell differentiation|
|regulation of sclerotome development|
|regulation of mesenchymal cell proliferation involved in prostate gland development|
|mesenchymal smoothened signaling pathway involved in prostate gland development|
|negative regulation of kidney smooth muscle cell differentiation|
|regulation of kidney smooth muscle cell differentiation|
|positive regulation of ureter smooth muscle cell differentiation|
|polarity specification of anterior/posterior axis|
|positive regulation of smooth muscle tissue development|
|negative regulation of ureter smooth muscle cell differentiation|
|tracheoesophageal septum formation|
|positive regulation of sclerotome development|
|negative regulation of smooth muscle tissue development|
|primary prostatic bud elongation|
|protein splicing|
|positive regulation of mesenchymal cell proliferation involved in ureter development|
|intein-mediated protein splicing|
|epithelial-mesenchymal signaling involved in prostate gland development|
|left lung development|
|right lung development|
|positive regulation of immature T cell proliferation in thymus|
|metanephric mesenchymal cell proliferation involved in metanephros development|
|bud outgrowth involved in lung branching|
|mesenchymal cell proliferation involved in lung development|
|positive regulation of epithelial cell proliferation involved in prostate gland development|
|regulation of mesenchymal cell proliferation involved in ureter development|
|positive regulation of immature T cell proliferation|
|negative regulation of dopaminergic neuron differentiation|
|positive regulation of hh target transcription factor activity|
|prostate epithelial cord elongation|
|positive regulation of skeletal muscle cell proliferation|
|kidney mesenchymal cell proliferation|
|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|
|negative regulation of cholesterol efflux|
|signal transduction downstream of smoothened|
|prostate gland morphogenetic growth|
|ventral midline development|
|specification of axis polarity|
|salivary gland cavitation|
|formation of anatomical boundary|
|regulation of nodal signaling pathway involved in determination of left/right asymmetry|
|epithelial cell proliferation involved in salivary gland morphogenesis|
|regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|tube lumen cavitation|
|determination of left/right asymmetry in lateral mesoderm|
|regulation of prostatic bud formation|
|regulation of immature T cell proliferation in thymus|
|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|
|epithelial-mesenchymal cell signaling|
|cell proliferation in external granule layer|
|laminin-1 binding|
|cerebellar granule cell precursor proliferation|
|cell proliferation in hindbrain|
|cell proliferation involved in metanephros development|
|lung lobe development|
|Bergmann glial cell differentiation|
|hindgut morphogenesis|
|morphogen activity|
|lung lobe morphogenesis|
|lung-associated mesenchyme development|
|regulation of nodal signaling pathway|
|regulation of immature T cell proliferation|
|patched binding|
|positive regulation of cerebellar granule cell precursor proliferation|
|hindgut development|
|embryonic foregut morphogenesis|
|negative regulation of mesenchymal cell apoptotic process|
|cell proliferation involved in kidney development|
|branching involved in prostate gland morphogenesis|
|regulation of dopaminergic neuron differentiation|
|foregut morphogenesis|
|regulation of epithelial cell proliferation involved in prostate gland development|
|regulation of cerebellar granule cell precursor proliferation|
|prostate gland growth|
|positive thymic T cell selection|
|positive regulation of T cell differentiation in thymus|
|trachea morphogenesis|
|limb bud formation|
|negative thymic T cell selection|
|negative regulation of cholesterol transport|
|positive regulation of smooth muscle cell differentiation|
|negative regulation of sterol transport|
|lymphoid progenitor cell differentiation|
|negative T cell selection|
|regulation of mesenchymal cell apoptotic process|
|negative regulation of transcription elongation from RNA polymerase II promoter|
|lateral mesoderm development|
|cellular response to lithium ion|
|telencephalon regionalization|
|thalamus development|
|regulation of skeletal muscle cell proliferation|
|metanephric mesenchyme development|
|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|
|negative regulation of DNA-templated transcription, elongation|
|mesenchymal cell proliferation|
|negative regulation of smooth muscle cell differentiation|
|negative regulation of kidney development|
|branching involved in salivary gland morphogenesis|
|dorsal/ventral neural tube patterning|
|branch elongation of an epithelium|
|regulation of mesoderm development|
|kidney mesenchyme development|
|embryonic digestive tract morphogenesis|
|osteoblast development|
|trachea development|
|thymic T cell selection|
|ectoderm development|
|T cell lineage commitment|
|response to lithium ion|
|positive regulation of neuroblast proliferation|
|spinal cord dorsal/ventral patterning|
|prostate gland epithelium morphogenesis|
|thyroid gland development|
|regulation of cholesterol efflux|
|positive regulation of oligodendrocyte differentiation|
|male genitalia development|
|intermediate filament organization|
|forebrain regionalization|
|prostate gland morphogenesis|
|spinal cord patterning|
|glycosaminoglycan binding|
|regulation of T cell differentiation in thymus|
|negative regulation of alpha-beta T cell differentiation|
|hair follicle morphogenesis|
|positive regulation of mesenchymal cell proliferation|
|regulation of activin receptor signaling pathway|
|positive regulation of skeletal muscle tissue development|
|positive T cell selection|
|epithelial tube branching involved in lung morphogenesis|
|negative regulation of lipid transport|
|regulation of odontogenesis|
|axis elongation|
|androgen metabolic process|
|embryonic hindlimb morphogenesis|
|branching involved in blood vessel morphogenesis|
|epidermis morphogenesis|
|salivary gland morphogenesis|
|lung epithelium development|
|regulation of transcription elongation from RNA polymerase II promoter|
|dopaminergic neuron differentiation|
|positive regulation of smoothened signaling pathway|
|neuroblast proliferation|
|regulation of smooth muscle cell differentiation|
|salivary gland development|
|regulation of neuroblast proliferation|
|regulation of mesenchymal cell proliferation|
|embryonic forelimb morphogenesis|
|spinal cord motor neuron differentiation|
|embryonic digestive tract development|
|animal organ formation|
|neural tube patterning|
|myoblast differentiation|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of animal organ formation|
|hindlimb morphogenesis|
|positive regulation of protein import into nucleus|
|positive regulation of embryonic development|
|negative regulation of alpha-beta T cell activation|
|T cell selection|
|positive regulation of protein import|
|regulation of oligodendrocyte differentiation|
|positive regulation of stem cell proliferation|
|positive regulation of kidney development|
|forelimb morphogenesis|
|prostate gland development|
|negative regulation of lipid localization|
|oligodendrocyte development|
|positive regulation of glial cell differentiation|
|lung morphogenesis|
|exocrine system development|
|negative regulation of T cell differentiation|
|branching involved in ureteric bud morphogenesis|
|regulation of cholesterol transport|
|thymus development|
|regulation of sterol transport|
|positive regulation of alpha-beta T cell differentiation|
|T cell differentiation in thymus|
|genitalia development|
|digestive tract morphogenesis|
|negative regulation of ubiquitin-dependent protein catabolic process|
|ventral spinal cord development|
|regulation of skeletal muscle tissue development|
|intermediate filament cytoskeleton organization|
|anterior/posterior axis specification|
|intermediate filament-based process|
|regulation of DNA-templated transcription, elongation|
|negative regulation of muscle tissue development|
|positive regulation of neural precursor cell proliferation|
|stem cell proliferation|
|astrocyte differentiation|
|negative regulation of lymphocyte differentiation|
|ureteric bud morphogenesis|
|cell differentiation in spinal cord|
|mesonephric tubule morphogenesis|
|negative regulation of muscle cell differentiation|
|regulation of kidney development|
|regulation of protein import into nucleus|
|neural crest cell migration|
|regulation of morphogenesis of a branching structure|
|negative regulation of proteasomal protein catabolic process|
|myotube differentiation|
|regulation of protein import|
|positive regulation of striated muscle cell differentiation|
|positive regulation of alpha-beta T cell activation|
|negative regulation of T cell proliferation|
|heart looping|
|embryonic digit morphogenesis|
|embryonic pattern specification|
|regulation of alpha-beta T cell differentiation|
|positive regulation of nucleocytoplasmic transport|
|neuron fate commitment|
|nephron tubule morphogenesis|
|regulation of stem cell proliferation|
|nephron epithelium morphogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|nephron morphogenesis|
|vasculogenesis|
|renal tubule morphogenesis|
|positive regulation of gliogenesis|
|oligodendrocyte differentiation|
|regulation of glial cell differentiation|
|positive regulation of muscle organ development|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle tissue development|
|hair follicle development|
|pancreas development|
|smoothened signaling pathway|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|skin epidermis development|
|positive regulation of protein localization to nucleus|
|molting cycle process|
|hair cycle process|
|negative regulation of lymphocyte proliferation|
|neural precursor cell proliferation|
|negative regulation of mononuclear cell proliferation|
|diencephalon development|
|embryonic heart tube development|
|regulation of smoothened signaling pathway|
|nephron tubule development|
|positive regulation of reproductive process|
|neural crest cell development|
|negative regulation of leukocyte proliferation|
|renal tubule development|
|dorsal/ventral pattern formation|
|peptidase activity|
|positive regulation of T cell differentiation|
|somite development|
|odontogenesis of dentin-containing tooth|
|stem cell development|
|mesenchymal cell development|
|metanephros development|
|kidney morphogenesis|
|artery development|
|axis specification|
|ureteric bud development|
|midbrain development|
|positive regulation of muscle cell differentiation|
|positive regulation of cell division|
|mesonephric epithelium development|
|negative regulation of cellular protein catabolic process|
|hematopoietic progenitor cell differentiation|
|epithelial cell proliferation|
|mesonephric tubule development|
|cell fate specification|
|regulation of neural precursor cell proliferation|
|neural crest cell differentiation|
|canonical Wnt signaling pathway|
|roof of mouth development|
|mesonephros development|
|molting cycle|
|hair cycle|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|positive regulation of T cell proliferation|
|organ growth|
|nephron epithelium development|
|gland morphogenesis|
|negative regulation of leukocyte differentiation|
|regulation of striated muscle cell differentiation|
|regulation of nucleocytoplasmic transport|
|spinal cord development|
|glial cell development|
|regulation of lipid transport|
|negative regulation of T cell activation|
|developmental growth involved in morphogenesis|
|regulation of gliogenesis|
|regulation of protein localization to nucleus|
|establishment of cell polarity|
|determination of left/right symmetry|
|odontogenesis|
|cellular hormone metabolic process|
|endocrine system development|
|negative regulation of leukocyte cell-cell adhesion|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|determination of bilateral symmetry|
|specification of symmetry|
|nephron development|
|mesoderm development|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|osteoblast differentiation|
|embryonic skeletal system development|
|regulation of embryonic development|
|kidney epithelium development|
|positive regulation of lymphocyte proliferation|
|digestive tract development|
|branching morphogenesis of an epithelial tube|
|positive regulation of mononuclear cell proliferation|
|regulation of striated muscle tissue development|
|negative regulation of protein catabolic process|
|T cell differentiation|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|negative regulation of hemopoiesis|
|positive regulation of leukocyte proliferation|
|regulation of T cell differentiation|
|regulation of lipid localization|
|digestive system development|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|tube formation|
|limb morphogenesis|
|appendage morphogenesis|
|hindbrain development|
|regulation of muscle cell differentiation|
|regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of intracellular protein transport|
|mesenchymal cell differentiation|
|male sex differentiation|
|regulation of T cell proliferation|
|protein processing|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|neural tube development|
|regulation of reproductive process|
|protein localization to nucleus|
|regulation of cell division|
|regulation of lymphocyte differentiation|
|morphogenesis of a branching structure|
|lung development|
|glial cell differentiation|
|ameboidal-type cell migration|
|respiratory tube development|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|negative regulation of canonical Wnt signaling pathway|
|positive regulation of Wnt signaling pathway|
|central nervous system neuron differentiation|
|limb development|
|appendage development|
|regulation of morphogenesis of an epithelium|
|regulation of proteasomal protein catabolic process|
|positive regulation of hemopoiesis|
|positive regulation of epithelial cell proliferation|
|cellular response to metal ion|
|inner ear development|
|respiratory system development|
|establishment or maintenance of cell polarity|
|negative regulation of cell activation|
|striated muscle cell differentiation|
|positive regulation of T cell activation|
|hormone metabolic process|
|positive regulation of intracellular transport|
|regulation of lymphocyte proliferation|
|negative regulation of Wnt signaling pathway|
|regulation of mononuclear cell proliferation|
|gliogenesis|
|anterior/posterior pattern specification|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of leukocyte cell-cell adhesion|
|cellular response to inorganic substance|
|mesenchyme development|
|ear development|
|regulation of leukocyte proliferation|
|protein maturation|
|negative regulation of neuron differentiation|
|membrane raft|
|regulation of intracellular protein transport|
|T cell activation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|lymphocyte differentiation|
|muscle cell differentiation|
|cell fate commitment|
|regulation of cellular protein catabolic process|
|heart morphogenesis|
|negative regulation of cellular catabolic process|
|positive regulation of cell-cell adhesion|
|telencephalon development|
|regulation of animal organ morphogenesis|
|negative regulation of cell migration|
|axon guidance|
|steroid metabolic process|
|ossification|
|neuron projection guidance|
|positive regulation of DNA-binding transcription factor activity|
|sex differentiation|
|kidney development|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cell motility|
|regulation of canonical Wnt signaling pathway|
|apoptotic signaling pathway|
|striated muscle tissue development|
|renal system development|
|embryonic organ morphogenesis|
|negative regulation of neurogenesis|
|blood coagulation|
|coagulation|
|muscle tissue development|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|endoplasmic reticulum lumen|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|negative regulation of catabolic process|
|negative regulation of nervous system development|
|camera-type eye development|
|regulation of T cell activation|
|angiogenesis|
|urogenital system development|
|negative regulation of locomotion|
|positive regulation of cellular protein localization|
|leukocyte differentiation|
|regionalization|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|eye development|
|positive regulation of lymphocyte activation|
|regulation of Wnt signaling pathway|
|visual system development|
|collagen-containing extracellular matrix|
|sensory system development|
|response to metal ion|
|axonogenesis|
|skin development|
|lymphocyte activation|
|regulation of protein catabolic process|
|forebrain development|
|developmental growth|
|growth|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|blood vessel morphogenesis|
|axon development|
|gland development|
|epidermis development|
|positive regulation of cell activation|
|positive regulation of protein transport|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|positive regulation of neurogenesis|
|muscle structure development|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|negative regulation of transport|
|blood vessel development|
|cell projection morphogenesis|
|skeletal system development|
|regulation of body fluid levels|
|vasculature development|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|cardiovascular system development|
|heart development|
|regulation of hormone levels|
|response to inorganic substance|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|sensory organ development|
|chemotaxis|
|taxis|
|cell population proliferation|
|endocytosis|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|chordate embryonic development|
|regulation of cell activation|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|developmental process involved in reproduction|
|import into cell|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of protein transport|
|negative regulation of cell differentiation|
|calcium ion binding|
|cell morphogenesis|
|regulation of proteolysis|
|protein localization to organelle|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|zinc ion binding|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|cell death|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|cellular protein localization|
|extracellular space|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
No hits were found.
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 12250
* **Expression level (log2 read counts)**: -0.59
{{:chemogenomics:nalm6 dist.png?nolink |}}