======= SHISA8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SHISA8
  * **<color #00a2e8>Official Name</color>**: shisa family member 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440829|440829]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/B8ZZ34|B8ZZ34]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SHISA8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHISA8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617329|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendritic spine membrane|
|regulation of short-term neuronal synaptic plasticity|
|regulation of AMPA receptor activity|
|AMPA glutamate receptor complex|
|regulation of neuronal synaptic plasticity|
|regulation of glutamate receptor signaling pathway|
|regulation of neurotransmitter receptor activity|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|synapse|
|regulation of transporter activity|
|regulation of cation transmembrane transport|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|regulation of ion transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.34|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.77|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.72|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.8|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9427
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SHISA8 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>