======= SHPK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SHPK
  * **<color #00a2e8>Official Name</color>**: sedoheptulokinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23729|23729]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHJ6|Q9UHJ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SHPK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHPK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605060|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a modulator of macrophage activation through control of glucose metabolism. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FGGY N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sedoheptulokinase activity|
|cellular response to interleukin-13|
|response to interleukin-13|
|pentose-phosphate shunt, non-oxidative branch|
|pentose-phosphate shunt|
|NADPH regeneration|
|glucose 6-phosphate metabolic process|
|NADP metabolic process|
|cellular response to interleukin-4|
|response to interleukin-4|
|regulation of macrophage activation|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|cellular response to biotic stimulus|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|cellular response to lipid|
|regulation of leukocyte activation|
|regulation of cell activation|
|response to bacterium|
|regulation of defense response|
|response to lipid|
|organophosphate metabolic process|
|oxidation-reduction process|
|cellular response to cytokine stimulus|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|regulation of response to external stimulus|
|response to cytokine|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|regulation of immune system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:madcam1|MADCAM1]]|0.447|
|[[:human genes:t:terf2|TERF2]]|0.432|
|[[:human genes:t:tfip11|TFIP11]]|0.427|
|[[:human genes:r:rpl37a|RPL37A]]|0.422|
|[[:human genes:g:gar1|GAR1]]|0.42|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.417|
|[[:human genes:t:tceb3c|TCEB3C]]|0.416|
|[[:human genes:u:usp36|USP36]]|0.416|
|[[:human genes:s:s1pr4|S1PR4]]|0.411|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.411|
|[[:human genes:a:ankle1|ANKLE1]]|0.41|
|[[:human genes:v:vasn|VASN]]|0.407|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2597
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SHPK Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>