======= SIRT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIRT1
  * **<color #00a2e8>Official Name</color>**: sirtuin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23411|23411]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EB6|Q96EB6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIRT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIRT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604479|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD(+)/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction. Is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT). Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. Deacetylates 'Lys-266' of SUV39H1, leading to its activation. Inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. Deacetylates H2A and 'Lys-26' of HIST1H1E. Deacetylates 'Lys-16' of histone H4 (in vitro). Involved in NR0B2/SHP corepression function through chromatin remodeling: Recruited to LRH1 target gene promoters by NR0B2/SHP thereby stimulating histone H3 and H4 deacetylation leading to transcriptional repression. Proposed to contribute to genomic integrity via positive regulation of telomere length; however, reports on localization to pericentromeric heterochromatin are conflicting. Proposed to play a role in constitutive heterochromatin (CH) formation and/or maintenance through regulation of the available pool of nuclear SUV39H1. Upon oxidative/metabolic stress decreases SUV39H1 degradation by inhibiting SUV39H1 polyubiquitination by MDM2. This increase in SUV39H1 levels enhances SUV39H1 turnover in CH, which in turn seems to accelerate renewal of the heterochromatin which correlates with greater genomic integrity during stress response. Deacetylates 'Lys-382' of p53/TP53 and impairs its ability to induce transcription-dependent proapoptotic program and modulate cell senescence. Deacetylates TAF1B and thereby represses rDNA transcription by the RNA polymerase I. Deacetylates MYC, promotes the association of MYC with MAX and decreases MYC stability leading to compromised transformational capability. Deacetylates FOXO3 in response to oxidative stress thereby increasing its ability to induce cell cycle arrest and resistance to oxidative stress but inhibiting FOXO3-mediated induction of apoptosis transcriptional activity; also leading to FOXO3 ubiquitination and protesomal degradation. Appears to have a similar effect on MLLT7/FOXO4 in regulation of transcriptional activity and apoptosis. Deacetylates DNMT1; thereby impairs DNMT1 methyltransferase-independent transcription repressor activity, modulates DNMT1 cell cycle regulatory function and DNMT1-mediated gene silencing. Deacetylates RELA/NF-kappa-B p65 thereby inhibiting its transactivating potential and augments apoptosis in response to TNF-alpha. Deacetylates HIF1A, KAT5/TIP60, RB1 and HIC1. Deacetylates FOXO1 resulting in its nuclear retention and enhancement of its transcriptional activity leading to increased gluconeogenesis in liver. Inhibits E2F1 transcriptional activity and apoptotic function, possibly by deacetylation. Involved in HES1- and HEY2-mediated transcriptional repression. In cooperation with MYCN seems to be involved in transcriptional repression of DUSP6/MAPK3 leading to MYCN stabilization by phosphorylation at 'Ser-62'. Deacetylates MEF2D. Required for antagonist-mediated transcription suppression of AR-dependent genes which may be linked to local deacetylation of histone H3. Represses HNF1A- mediated transcription. Required for the repression of ESRRG by CREBZF. Modulates AP-1 transcription factor activity. Deacetylates NR1H3 AND NR1H2 and deacetylation of NR1H3 at 'Lys-434' positively regulates transcription of NR1H3:RXR target genes, promotes NR1H3 proteosomal degradation and results in cholesterol efflux; a promoter clearing mechanism after reach round of transcription is proposed. Involved in lipid metabolism. Implicated in regulation of adipogenesis and fat mobilization in white adipocytes by repression of PPARG which probably involves association with NCOR1 and SMRT/NCOR2. Deacetylates ACSS2 leading to its activation, and HMGCS1. Involved in liver and muscle metabolism. Through deacteylation and activation of PPARGC1A is required to activate fatty acid oxidation in skeletel muscle under low-glucose conditions and is involved in glucose homeostasis. Involved in regulation of PPARA and fatty acid beta-oxidation in liver. Involved in positive regulation of insulin secretion in pancreatic beta cells in response to glucose; the function seems to imply transcriptional repression of UCP2. Proposed to deacetylate IRS2 thereby facilitating its insulin-induced tyrosine phosphorylation. Deacetylates SREBF1 isoform SREBP-1C thereby decreasing its stability and transactivation in lipogenic gene expression. Involved in DNA damage response by repressing genes which are involved in DNA repair, such as XPC and TP73, deacetylating XRCC6/Ku70, and faciliting recruitment of additional factors to sites of damaged DNA, such as SIRT1-deacetylated NBN can recruit ATM to initiate DNA repair and SIRT1-deacetylated XPA interacts with RPA2. Also involved in DNA repair of DNA double-strand breaks by homologous recombination and specifically single-strand annealing independently of XRCC6/Ku70 and NBN. Transcriptional suppression of XPC probably involves an E2F4:RBL2 suppressor complex and protein kinase B (AKT) signaling. Transcriptional suppression of TP73 probably involves E2F4 and PCAF. Deacetylates WRN thereby regulating its helicase and exonuclease activities and regulates WRN nuclear translocation in response to DNA damage. Deacetylates APEX1 at 'Lys-6' and 'Lys-7' and stimulates cellular AP endonuclease activity by promoting the association of APEX1 to XRCC1. Increases p53/TP53-mediated transcription-independent apoptosis by blocking nuclear translocation of cytoplasmic p53/TP53 and probably redirecting it to mitochondria. Deacetylates XRCC6/Ku70 at 'Lys-539' and 'Lys-542' causing it to sequester BAX away from mitochondria thereby inhibiting stress-induced apoptosis. Is involved in autophagy, presumably by deacetylating ATG5, ATG7 and MAP1LC3B/ATG8. Deacetylates AKT1 which leads to enhanced binding of AKT1 and PDK1 to PIP3 and promotes their activation. Proposed to play role in regulation of STK11/LBK1- dependent AMPK signaling pathways implicated in cellular senescence which seems to involve the regulation of the acetylation status of STK11/LBK1. Can deacetylate STK11/LBK1 and thereby increase its activity, cytoplasmic localization and association with STRAD; however, the relevance of such activity in normal cells is unclear. In endothelial cells is shown to inhibit STK11/LBK1 activity and to promote its degradation. Deacetylates SMAD7 at 'Lys-64' and 'Lys-70' thereby promoting its degradation. Deacetylates CIITA and augments its MHC class II transactivation and contributes to its stability. Deacteylates MECOM/EVI1. Deacetylates PML at 'Lys-487' and this deacetylation promotes PML control of PER2 nuclear localization. During the neurogenic transition, repress selective NOTCH1-target genes through histone deacetylation in a BCL6-dependent manner and leading to neuronal differentiation. Regulates the circadian expression of several core clock genes, including ARNTL/BMAL1, RORC, PER2 and CRY1 and plays a critical role in maintaining a controlled rhythmicity in histone acetylation, thereby contributing to circadian chromatin remodeling. Deacetylates ARNTL/BMAL1 and histones at the circadian gene promoters in order to facilitate repression by inhibitory components of the circadian oscillator. Deacetylates PER2, facilitating its ubiquitination and degradation by the proteosome. Protects cardiomyocytes against palmitate-induced apoptosis (PubMed:11672523, PubMed:12006491, PubMed:14976264, PubMed:14980222, PubMed:15126506, PubMed:15152190, PubMed:15205477, PubMed:15469825, PubMed:15692560, PubMed:16079181, PubMed:16166628, PubMed:16892051, PubMed:16998810, PubMed:17283066, PubMed:17334224, PubMed:17505061, PubMed:17612497, PubMed:17620057, PubMed:17936707, PubMed:18203716, PubMed:18296641, PubMed:18662546, PubMed:18687677, PubMed:19188449, PubMed:19220062, PubMed:19364925, PubMed:19690166, PubMed:19934257, PubMed:20097625, PubMed:20100829, PubMed:20203304, PubMed:20375098, PubMed:20620956, PubMed:20670893, PubMed:20817729, PubMed:21149730, PubMed:21245319, PubMed:21471201, PubMed:21504832, PubMed:21555002, PubMed:21698133, PubMed:21701047, PubMed:21775285, PubMed:21807113, PubMed:21841822, PubMed:21890893, PubMed:21909281, PubMed:21947282, PubMed:22274616). Deacetylates XBP1 isoform 2; deacetylation decreases protein stability of XBP1 isoform 2 and inhibits its transcriptional activity (PubMed:20955178). Involved in the CCAR2- mediated regulation of PCK1 and NR1D1 (PubMed:24415752). Deacetylates CTNB1 at 'Lys-49' (PubMed:24824780). In POMC (pro- opiomelanocortin) neurons, required for leptin-induced activation of PI3K signaling (By similarity). {ECO:0000250|UniProtKB:Q923E4, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:14976264, ECO:0000269|PubMed:14980222, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:15152190, ECO:0000269|PubMed:15205477, ECO:0000269|PubMed:15469825, ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16892051, ECO:0000269|PubMed:16998810, ECO:0000269|PubMed:17283066, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:17334224, ECO:0000269|PubMed:17505061, ECO:0000269|PubMed:17612497, ECO:0000269|PubMed:17620057, ECO:0000269|PubMed:17936707, ECO:0000269|PubMed:18203716, ECO:0000269|PubMed:18296641, ECO:0000269|PubMed:18662546, ECO:0000269|PubMed:18687677, ECO:0000269|PubMed:19188449, ECO:0000269|PubMed:19220062, ECO:0000269|PubMed:19364925, ECO:0000269|PubMed:19690166, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:20097625, ECO:0000269|PubMed:20100829, ECO:0000269|PubMed:20203304, ECO:0000269|PubMed:20375098, ECO:0000269|PubMed:20620956, ECO:0000269|PubMed:20670893, ECO:0000269|PubMed:20817729, ECO:0000269|PubMed:20955178, ECO:0000269|PubMed:21149730, ECO:0000269|PubMed:21245319, ECO:0000269|PubMed:21471201, ECO:0000269|PubMed:21504832, ECO:0000269|PubMed:21555002, ECO:0000269|PubMed:21698133, ECO:0000269|PubMed:21701047, ECO:0000269|PubMed:21775285, ECO:0000269|PubMed:21807113, ECO:0000269|PubMed:21841822, ECO:0000269|PubMed:21890893, ECO:0000269|PubMed:21909281, ECO:0000269|PubMed:21947282, ECO:0000269|PubMed:22274616, ECO:0000269|PubMed:24415752, ECO:0000269|PubMed:24824780}. (Microbial infection) In case of HIV-1 infection, interacts with and deacetylates the viral Tat protein. The viral Tat protein inhibits SIRT1 deacetylation activity toward RELA/NF- kappa-B p65, thereby potentiates its transcriptional activity and SIRT1 is proposed to contribute to T-cell hyperactivation during infection. {ECO:0000269|PubMed:18329615}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SIR2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of histone H3-K14 acetylation|
|negative regulation of cellular response to testosterone stimulus|
|regulation of cellular response to testosterone stimulus|
|histone H3-K9 deacetylation|
|establishment of chromatin silencing|
|behavioral response to starvation|
|negative regulation of prostaglandin biosynthetic process|
|NAD-dependent histone deacetylase activity (H3-K9 specific)|
|macrophage cytokine production|
|negative regulation of histone H4-K16 acetylation|
|HLH domain binding|
|positive regulation of macrophage apoptotic process|
|pyrimidine dimer repair by nucleotide-excision repair|
|triglyceride mobilization|
|NAD-dependent histone deacetylase activity|
|maintenance of chromatin silencing|
|myeloid leukocyte cytokine production|
|negative regulation of helicase activity|
|rDNA heterochromatin|
|negative regulation of histone H3-K9 trimethylation|
|positive regulation of cAMP-dependent protein kinase activity|
|NAD-dependent protein deacetylase activity|
|negative regulation of histone H4 acetylation|
|regulation of histone H3-K14 acetylation|
|positive regulation of adipose tissue development|
|keratin filament binding|
|regulation of histone H4-K16 acetylation|
|single strand break repair|
|cellular triglyceride homeostasis|
|chromatin silencing complex|
|negative regulation of cAMP-dependent protein kinase activity|
|positive regulation of myeloid cell apoptotic process|
|stress-induced premature senescence|
|peptidyl-lysine deacetylation|
|regulation of endodeoxyribonuclease activity|
|regulation of prostaglandin biosynthetic process|
|ovulation from ovarian follicle|
|regulation of adipose tissue development|
|pyrimidine dimer repair|
|regulation of deoxyribonuclease activity|
|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|leptin-mediated signaling pathway|
|regulation of macrophage apoptotic process|
|regulation of bile acid biosynthetic process|
|positive regulation of MHC class II biosynthetic process|
|regulation of unsaturated fatty acid biosynthetic process|
|negative regulation of histone H3-K9 methylation|
|regulation of histone H3-K9 trimethylation|
|positive regulation of histone H3-K9 methylation|
|protein deacetylase activity|
|regulation of helicase activity|
|chromatin silencing at rDNA|
|positive regulation of smooth muscle cell differentiation|
|deacetylase activity|
|regulation of bile acid metabolic process|
|positive regulation of cellular senescence|
|methylation-dependent chromatin silencing|
|positive regulation of gluconeogenesis|
|white fat cell differentiation|
|regulation of histone H4 acetylation|
|positive regulation of chromatin silencing|
|UV-damage excision repair|
|fatty acid homeostasis|
|regulation of MHC class II biosynthetic process|
|regulation of peroxisome proliferator activated receptor signaling pathway|
|negative regulation of fatty acid biosynthetic process|
|negative regulation of DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell aging|
|negative regulation of androgen receptor signaling pathway|
|negative regulation of histone acetylation|
|ESC/E(Z) complex|
|NAD+ binding|
|regulation of cAMP-dependent protein kinase activity|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|positive regulation of cholesterol efflux|
|regulation of brown fat cell differentiation|
|negative regulation of peptidyl-lysine acetylation|
|negative regulation of cellular senescence|
|ovulation|
|cellular response to leptin stimulus|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|histone H3-K9 modification|
|negative regulation of ATPase activity|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|histone H3 deacetylation|
|negative regulation of histone methylation|
|negative regulation of protein acetylation|
|nuclear heterochromatin|
|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|response to leptin|
|cytokine production involved in immune response|
|regulation of nuclease activity|
|positive regulation of insulin receptor signaling pathway|
|mitogen-activated protein kinase binding|
|regulation of cholesterol efflux|
|positive regulation of cholesterol transport|
|positive regulation of sterol transport|
|regulation of histone H3-K9 methylation|
|macrophage differentiation|
|positive regulation of cellular response to insulin stimulus|
|negative regulation of cell aging|
|regulation of smooth muscle cell apoptotic process|
|negative regulation of fatty acid metabolic process|
|bHLH transcription factor binding|
|regulation of androgen receptor signaling pathway|
|nuclear hormone receptor binding|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|NAD+ ADP-ribosyltransferase activity|
|histone deacetylase activity|
|positive regulation of leukocyte apoptotic process|
|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|
|regulation of myeloid cell apoptotic process|
|protein ADP-ribosylation|
|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|
|nuclear euchromatin|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of smooth muscle cell differentiation|
|negative regulation of signal transduction by p53 class mediator|
|cellular senescence|
|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|acylglycerol homeostasis|
|triglyceride homeostasis|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of response to endoplasmic reticulum stress|
|regulation of chromatin silencing|
|positive regulation of glucose metabolic process|
|positive regulation of histone methylation|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of cellular senescence|
|negative regulation of histone modification|
|negative regulation of I-kappaB kinase/NF-kappaB signaling|
|ovulation cycle process|
|regulation of cholesterol transport|
|regulation of lipid storage|
|negative regulation of cellular response to oxidative stress|
|negative regulation of oxidative stress-induced cell death|
|regulation of fatty acid biosynthetic process|
|regulation of gluconeogenesis|
|negative regulation of protein kinase B signaling|
|regulation of sterol transport|
|protein destabilization|
|nuclear inner membrane|
|negative regulation of fat cell differentiation|
|negative regulation of response to oxidative stress|
|regulation of cell aging|
|negative regulation of lipid biosynthetic process|
|negative regulation of TOR signaling|
|histone deacetylation|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|protein deacetylation|
|DNA synthesis involved in DNA repair|
|positive regulation of blood vessel endothelial cell migration|
|regulation of histone acetylation|
|anion homeostasis|
|positive regulation of intrinsic apoptotic signaling pathway|
|positive regulation of cellular carbohydrate metabolic process|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|negative regulation of chromatin organization|
|protein deacylation|
|positive regulation of lipid transport|
|regulation of peptidyl-lysine acetylation|
|macromolecule deacylation|
|circadian regulation of gene expression|
|regulation of oxidative stress-induced cell death|
|regulation of insulin receptor signaling pathway|
|cell aging|
|regulation of histone methylation|
|p53 binding|
|positive regulation of DNA repair|
|positive regulation of macroautophagy|
|ovulation cycle|
|regulation of muscle cell apoptotic process|
|cellular response to ionizing radiation|
|chromatin organization involved in regulation of transcription|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|cellular response to hydrogen peroxide|
|regulation of protein acetylation|
|regulation of cellular response to insulin stimulus|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|triglyceride metabolic process|
|regulation of cellular response to oxidative stress|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of cellular response to heat|
|cholesterol homeostasis|
|positive regulation of carbohydrate metabolic process|
|negative regulation of response to DNA damage stimulus|
|sterol homeostasis|
|negative regulation of gene expression, epigenetic|
|positive regulation of lipid localization|
|regulation of ATPase activity|
|negative regulation of NF-kappaB transcription factor activity|
|regulation of leukocyte apoptotic process|
|negative regulation of lipid metabolic process|
|cellular response to UV|
|regulation of response to endoplasmic reticulum stress|
|regulation of response to oxidative stress|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|regulation of fatty acid metabolic process|
|positive regulation of muscle cell differentiation|
|cellular glucose homeostasis|
|female gonad development|
|regulation of steroid biosynthetic process|
|regulation of blood vessel endothelial cell migration|
|negative regulation of small molecule metabolic process|
|positive regulation of histone modification|
|development of primary female sexual characteristics|
|positive regulation of endothelial cell proliferation|
|regulation of carbohydrate biosynthetic process|
|negative regulation of intrinsic apoptotic signaling pathway|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|acylglycerol metabolic process|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|positive regulation of endothelial cell migration|
|positive regulation of response to DNA damage stimulus|
|PML body|
|neutral lipid metabolic process|
|transforming growth factor beta receptor signaling pathway|
|regulation of TOR signaling|
|positive regulation of chromatin organization|
|positive regulation of adaptive immune response|
|fat cell differentiation|
|female sex differentiation|
|regulation of lipid transport|
|DNA biosynthetic process|
|nucleotide-excision repair|
|myeloid leukocyte differentiation|
|cellular response to light stimulus|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of glucose metabolic process|
|regulation of steroid metabolic process|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of autophagy|
|signal transduction by p53 class mediator|
|peptidyl-lysine acetylation|
|regulation of fat cell differentiation|
|regulation of DNA repair|
|regulation of endothelial cell proliferation|
|regulation of gene silencing|
|female gamete generation|
|cellular response to reactive oxygen species|
|histone binding|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of protein serine/threonine kinase activity|
|lipid homeostasis|
|negative regulation of chromosome organization|
|regulation of lipid localization|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|positive regulation of epithelial cell migration|
|circadian rhythm|
|response to UV|
|protein acetylation|
|regulation of histone modification|
|negative regulation of cellular response to growth factor stimulus|
|response to ionizing radiation|
|intrinsic apoptotic signaling pathway|
|cytokine production|
|positive regulation of cysteine-type endopeptidase activity|
|cellular response to starvation|
|gene silencing|
|regulation of muscle cell differentiation|
|cellular response to transforming growth factor beta stimulus|
|regulation of endothelial cell migration|
|regulation of intrinsic apoptotic signaling pathway|
|negative regulation of DNA-binding transcription factor activity|
|regulation of adaptive immune response|
|response to transforming growth factor beta|
|positive regulation of angiogenesis|
|regulation of cellular ketone metabolic process|
|positive regulation of endopeptidase activity|
|regulation of macroautophagy|
|positive regulation of chromosome organization|
|cellular response to radiation|
|positive regulation of apoptotic signaling pathway|
|nuclear envelope|
|production of molecular mediator of immune response|
|regulation of signal transduction by p53 class mediator|
|negative regulation of cell growth|
|positive regulation of vasculature development|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of lipid biosynthetic process|
|cellular response to hypoxia|
|protein acylation|
|regulation of chromatin organization|
|protein C-terminus binding|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidase activity|
|positive regulation of DNA metabolic process|
|response to starvation|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of carbohydrate metabolic process|
|negative regulation of neuron death|
|gonad development|
|rRNA processing|
|cellular response to toxic substance|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to oxygen levels|
|development of primary sexual characteristics|
|regulation of response to DNA damage stimulus|
|regulation of epithelial cell migration|
|myeloid cell differentiation|
|regulation of protein kinase B signaling|
|rRNA metabolic process|
|negative regulation of protein kinase activity|
|negative regulation of apoptotic signaling pathway|
|response to insulin|
|cellular response to nutrient levels|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|cellular response to tumor necrosis factor|
|cellular response to oxidative stress|
|transcription corepressor activity|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|negative regulation of kinase activity|
|response to tumor necrosis factor|
|cellular response to extracellular stimulus|
|sex differentiation|
|regulation of cellular response to growth factor stimulus|
|negative regulation of transferase activity|
|rhythmic process|
|aging|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|regulation of protein stability|
|muscle organ development|
|ribosome biogenesis|
|response to antibiotic|
|response to light stimulus|
|regulation of neuron death|
|peptidyl-lysine modification|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|angiogenesis|
|regulation of vasculature development|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|leukocyte differentiation|
|regulation of autophagy|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|positive regulation of protein serine/threonine kinase activity|
|response to hypoxia|
|enzyme binding|
|proteasomal protein catabolic process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|glycerolipid metabolic process|
|response to oxygen levels|
|ncRNA processing|
|response to oxidative stress|
|response to peptide hormone|
|regulation of lipid metabolic process|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|blood vessel morphogenesis|
|regulation of cell growth|
|regulation of endopeptidase activity|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|regulation of small molecule metabolic process|
|reproductive system development|
|positive regulation of catabolic process|
|response to radiation|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|negative regulation of hydrolase activity|
|ribonucleoprotein complex biogenesis|
|response to peptide|
|ncRNA metabolic process|
|muscle structure development|
|blood vessel development|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|DNA repair|
|vasculature development|
|regulation of protein serine/threonine kinase activity|
|cardiovascular system development|
|positive regulation of cell motility|
|ubiquitin-dependent protein catabolic process|
|response to extracellular stimulus|
|response to growth factor|
|modification-dependent protein catabolic process|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of cellular component movement|
|spermatogenesis|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|hemopoiesis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|male gamete generation|
|positive regulation of kinase activity|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|tube morphogenesis|
|positive regulation of transferase activity|
|developmental process involved in reproduction|
|regulation of growth|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|gamete generation|
|positive regulation of cell death|
|chromatin organization|
|viral process|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|DNA metabolic process|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|symbiotic process|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|RNA processing|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|response to hormone|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of catabolic process|
|regulation of cellular component movement|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|chromosome organization|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-1.86|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.74|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.73|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.76|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.8|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|1.86|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.87|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|1.88|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.93|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.12|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.38|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12411
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIRT1 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>