======= SIRT5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIRT5
  * **<color #00a2e8>Official Name</color>**: sirtuin 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23408|23408]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NXA8|Q9NXA8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIRT5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIRT5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604483|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. {ECO:0000250|UniProtKB:Q8K2C6, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24140062, ECO:0000269|PubMed:24703693}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SIR2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-glutaryllysine deglutarylase activity|
|protein deglutarylation|
|protein-malonyllysine demalonylase activity|
|peptidyl-lysine deglutarylation|
|peptidyl-lysine desuccinylation|
|peptidyl-lysine demalonylation|
|protein desuccinylation|
|protein demalonylation|
|protein-succinyllysine desuccinylase activity|
|NAD-dependent protein deacetylase activity|
|regulation of ketone biosynthetic process|
|NAD+ binding|
|negative regulation of cardiac muscle cell apoptotic process|
|negative regulation of striated muscle cell apoptotic process|
|NAD+ ADP-ribosyltransferase activity|
|protein ADP-ribosylation|
|regulation of cardiac muscle cell apoptotic process|
|negative regulation of muscle cell apoptotic process|
|regulation of striated muscle cell apoptotic process|
|protein deacetylation|
|negative regulation of reactive oxygen species metabolic process|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|protein deacylation|
|macromolecule deacylation|
|regulation of muscle cell apoptotic process|
|chromatin organization involved in regulation of transcription|
|mitochondrial intermembrane space|
|negative regulation of gene expression, epigenetic|
|gene silencing|
|regulation of cellular ketone metabolic process|
|regulation of reactive oxygen species metabolic process|
|regulation of gene expression, epigenetic|
|peptidyl-lysine modification|
|mitochondrial matrix|
|mitochondrial inner membrane|
|regulation of small molecule metabolic process|
|mitochondrion organization|
|response to nutrient levels|
|response to extracellular stimulus|
|chromatin organization|
|zinc ion binding|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of cell death|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.11|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17813
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIRT5 Expression in NALM6 Cells: 4.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>