======= SKIL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SKIL
  * **<color #00a2e8>Official Name</color>**: SKI like proto-oncogene
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6498|6498]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12757|P12757]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SKIL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SKIL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165340|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May have regulatory role in cell division or differentiation in response to extracellular signals.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|c-SKI SMAD bind|
|Ski Sno|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|lens fiber cell differentiation|
|blastocyst formation|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of extrinsic apoptotic signaling pathway|
|negative regulation of BMP signaling pathway|
|SMAD binding|
|lymphocyte homeostasis|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of intrinsic apoptotic signaling pathway|
|leukocyte homeostasis|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|lens development in camera-type eye|
|positive regulation of axonogenesis|
|acrosomal vesicle|
|regulation of BMP signaling pathway|
|blastocyst development|
|positive regulation of response to DNA damage stimulus|
|transforming growth factor beta receptor signaling pathway|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell cycle arrest|
|negative regulation of cellular response to growth factor stimulus|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of cell morphogenesis involved in differentiation|
|cellular response to transforming growth factor beta stimulus|
|regulation of intrinsic apoptotic signaling pathway|
|response to transforming growth factor beta|
|positive regulation of apoptotic signaling pathway|
|regulation of axonogenesis|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|homeostasis of number of cells|
|regulation of response to DNA damage stimulus|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|regulation of cellular response to growth factor stimulus|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|camera-type eye development|
|eye development|
|visual system development|
|positive regulation of neuron differentiation|
|sensory system development|
|in utero embryonic development|
|positive regulation of cell projection organization|
|chromatin binding|
|regulation of apoptotic signaling pathway|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|spermatogenesis|
|sensory organ development|
|male gamete generation|
|negative regulation of cell cycle|
|protein-containing complex|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|epithelial cell differentiation|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|neuron development|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|embryo development|
|multi-organism reproductive process|
|cell cycle process|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|epithelium development|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.88|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.78|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.78|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.7|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.84|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.97|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9950
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SKIL Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>