======= SLC17A7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC17A7
  * **<color #00a2e8>Official Name</color>**: solute carrier family 17 member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57030|57030]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2U7|Q9P2U7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC17A7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC17A7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605208|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:10820226}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extracellularly glutamate-gated chloride channel activity|
|synaptic vesicle lumen acidification|
|sequestering of neurotransmitter|
|sodium:inorganic phosphate symporter activity|
|clathrin-sculpted glutamate transport vesicle membrane|
|sodium-dependent phosphate transmembrane transporter activity|
|sodium-dependent phosphate transport|
|cerebellar mossy fiber|
|neurotransmitter transmembrane transporter activity|
|neurotransmitter loading into synaptic vesicle|
|L-glutamate import|
|L-glutamate transmembrane transporter activity|
|synaptic vesicle maturation|
|regulation of synaptic vesicle endocytosis|
|L-glutamate transmembrane transport|
|amino acid import|
|phosphate ion transport|
|regulation of synaptic vesicle recycling|
|synaptic transmission, glutamatergic|
|glutamate secretion|
|excitatory synapse|
|long-term memory|
|neuron cellular homeostasis|
|integral component of synaptic vesicle membrane|
|presynaptic active zone|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|neural retina development|
|L-amino acid transport|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|synaptic vesicle membrane|
|drug transmembrane transport|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|acid secretion|
|postsynapse|
|chloride transmembrane transport|
|sodium ion transmembrane transport|
|regulation of postsynaptic membrane potential|
|chloride transport|
|inorganic anion transmembrane transport|
|regulation of synaptic vesicle cycle|
|memory|
|amino acid transport|
|synaptic vesicle cycle|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|vesicle-mediated transport in synapse|
|retina development in camera-type eye|
|proton transmembrane transport|
|drug transport|
|sodium ion transport|
|inorganic anion transport|
|maintenance of location|
|neurotransmitter transport|
|regulation of endocytosis|
|regulation of synapse structure or activity|
|developmental maturation|
|learning or memory|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|cognition|
|vesicle organization|
|camera-type eye development|
|anatomical structure homeostasis|
|regulation of neurotransmitter levels|
|eye development|
|visual system development|
|sensory system development|
|monovalent inorganic cation transport|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|sensory organ development|
|cell junction|
|regulation of vesicle-mediated transport|
|inorganic cation transmembrane transport|
|behavior|
|anion transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|brain development|
|head development|
|cation transport|
|cellular homeostasis|
|regulation of cellular localization|
|ion transmembrane transport|
|central nervous system development|
|secretion by cell|
|response to drug|
|export from cell|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|ion transport|
|nervous system process|
|homeostatic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC17A7 Expression in NALM6 Cells: 1.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>