======= SLC17A8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC17A8
  * **<color #00a2e8>Official Name</color>**: solute carrier family 17 member 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=246213|246213]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NDX2|Q8NDX2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC17A8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC17A8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607557|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:12151341}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pericellular basket|
|glial limiting end-foot|
|basal dendrite|
|neurotransmitter transmembrane transporter activity|
|neurotransmitter loading into synaptic vesicle|
|L-glutamate transmembrane transporter activity|
|apical dendrite|
|L-glutamate transmembrane transport|
|synaptic transmission, glutamatergic|
|excitatory synapse|
|multivesicular body|
|integral component of synaptic vesicle membrane|
|symporter activity|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|cochlea development|
|axon terminus|
|neural retina development|
|L-amino acid transport|
|synaptic vesicle membrane|
|drug transmembrane transport|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|amino acid transport|
|synaptic vesicle cycle|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|vesicle-mediated transport in synapse|
|perikaryon|
|retina development in camera-type eye|
|sensory perception of sound|
|drug transport|
|sodium ion transport|
|sensory perception of mechanical stimulus|
|neurotransmitter transport|
|inner ear development|
|ear development|
|regulation of synapse structure or activity|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|monovalent inorganic cation transport|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|sensory organ development|
|cell junction|
|anion transport|
|metal ion transport|
|brain development|
|head development|
|cation transport|
|ion transmembrane transport|
|sensory perception|
|central nervous system development|
|response to drug|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3180
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC17A8 Expression in NALM6 Cells: -1.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>