======= SLC1A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC1A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 1 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6505|6505]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43005|P43005]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC1A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC1A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/133550|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7914198, ECO:0000269|PubMed:8857541}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SDF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cysteine transmembrane transport|
|cysteine transmembrane transporter activity|
|L-aspartate import across plasma membrane|
|cysteine transport|
|glutamate:sodium symporter activity|
|D-aspartate import across plasma membrane|
|D-aspartate transport|
|high-affinity glutamate transmembrane transporter activity|
|D-amino acid transport|
|sulfur amino acid transport|
|L-aspartate transmembrane transport|
|L-glutamate import across plasma membrane|
|L-glutamate import|
|glutamate binding|
|L-glutamate transmembrane transporter activity|
|amino acid import across plasma membrane|
|chloride transmembrane transporter activity|
|L-glutamate transmembrane transport|
|amino acid import|
|C4-dicarboxylate transport|
|positive regulation of heart rate|
|neurotransmitter uptake|
|glutamate secretion|
|neutral amino acid transport|
|positive regulation of heart contraction|
|sulfur compound transport|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|L-amino acid transport|
|drug transmembrane transport|
|positive regulation of blood circulation|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|acid secretion|
|recycling endosome membrane|
|chloride transmembrane transport|
|regulation of heart rate|
|import across plasma membrane|
|chloride transport|
|inorganic anion transmembrane transport|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|drug transport|
|early endosome membrane|
|inorganic anion transport|
|neurotransmitter transport|
|regulation of heart contraction|
|anion transmembrane transport|
|regulation of blood circulation|
|organic acid transport|
|carboxylic acid transport|
|apical plasma membrane|
|protein homooligomerization|
|regulation of neurotransmitter levels|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|protein complex oligomerization|
|anion transport|
|regulation of system process|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|import into cell|
|cation transport|
|ion transmembrane transport|
|secretion by cell|
|response to drug|
|export from cell|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|protein-containing complex assembly|
|positive regulation of multicellular organismal process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15670
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC1A1 Expression in NALM6 Cells: -4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>