======= SLC1A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC1A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 1 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6506|6506]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43004|P43004]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC1A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC1A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600300|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P43006, ECO:0000269|PubMed:15265858, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:7521911}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SDF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glutamate:sodium symporter activity|
|high-affinity glutamate transmembrane transporter activity|
|D-aspartate import across plasma membrane|
|D-aspartate transport|
|D-amino acid transport|
|L-glutamate import across plasma membrane|
|L-glutamate import|
|L-glutamate transmembrane transporter activity|
|axolemma|
|neurotransmitter reuptake|
|amino acid import across plasma membrane|
|L-glutamate transmembrane transport|
|amino acid import|
|C4-dicarboxylate transport|
|glutamate secretion|
|neurotransmitter uptake|
|protein homotrimerization|
|multicellular organism aging|
|positive regulation of glucose import|
|positive regulation of glucose transmembrane transport|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|visual behavior|
|protein trimerization|
|regulation of glucose import|
|integral component of presynaptic membrane|
|L-amino acid transport|
|drug transmembrane transport|
|regulation of glucose transmembrane transport|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|acid secretion|
|multicellular organism growth|
|import across plasma membrane|
|response to amino acid|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|adult behavior|
|drug transport|
|neurotransmitter transport|
|positive regulation of transmembrane transport|
|telencephalon development|
|cellular response to extracellular stimulus|
|anion transmembrane transport|
|aging|
|carboxylic acid transport|
|organic acid transport|
|response to light stimulus|
|cellular response to external stimulus|
|protein homooligomerization|
|response to acid chemical|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|forebrain development|
|developmental growth|
|growth|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|response to radiation|
|organic anion transport|
|synaptic signaling|
|protein complex oligomerization|
|response to extracellular stimulus|
|regulation of transmembrane transport|
|behavior|
|response to wounding|
|anion transport|
|cell surface|
|import into cell|
|brain development|
|head development|
|ion transmembrane transport|
|central nervous system development|
|positive regulation of transport|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|response to nitrogen compound|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.42|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.78|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.99|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.533|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15235
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC1A2 Expression in NALM6 Cells: 2.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>