======= SLC22A6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC22A6
  * **<color #00a2e8>Official Name</color>**: solute carrier family 22 member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9356|9356]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4U2R8|Q4U2R8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC22A6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC22A6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607582|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
|Sugar tr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal tubular secretion|
|alpha-ketoglutarate transport|
|response to methotrexate|
|organic anion transmembrane transporter activity|
|chloride ion binding|
|inorganic anion exchanger activity|
|response to antimetabolite|
|sodium-independent organic anion transmembrane transporter activity|
|sodium-independent organic anion transport|
|anion:anion antiporter activity|
|cofactor transport|
|caveola|
|dicarboxylic acid transport|
|response to antineoplastic agent|
|renal system process|
|inorganic anion transport|
|basolateral plasma membrane|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|protein homooligomerization|
|response to acid chemical|
|organic anion transport|
|protein complex oligomerization|
|anion transport|
|protein-containing complex|
|protein homodimerization activity|
|response to organic cyclic compound|
|ion transmembrane transport|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|secretion|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.72|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.76|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.87|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.07|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kctd17|KCTD17]]|0.409|
|[[:human genes:s:slc4a1|SLC4A1]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2404
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC22A6 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>