======= SLC25A13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A13
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10165|10165]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJS0|Q9UJS0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603859|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. {ECO:0000269|PubMed:11566871}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|malate-aspartate shuttle|
|L-aspartate transmembrane transporter activity|
|L-aspartate transmembrane transport|
|aspartate transmembrane transport|
|L-glutamate transmembrane transporter activity|
|L-glutamate transmembrane transport|
|C4-dicarboxylate transport|
|ATP biosynthetic process|
|gluconeogenesis|
|purine ribonucleoside triphosphate biosynthetic process|
|L-alpha-amino acid transmembrane transport|
|purine nucleoside triphosphate biosynthetic process|
|acidic amino acid transport|
|hexose biosynthetic process|
|ribonucleoside triphosphate biosynthetic process|
|monosaccharide biosynthetic process|
|L-amino acid transport|
|purine ribonucleoside triphosphate metabolic process|
|nucleoside triphosphate biosynthetic process|
|ribonucleoside triphosphate metabolic process|
|purine nucleoside triphosphate metabolic process|
|drug transmembrane transport|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|nucleoside triphosphate metabolic process|
|mitochondrial transmembrane transport|
|respiratory electron transport chain|
|glucose metabolic process|
|amino acid transport|
|carbohydrate biosynthetic process|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|purine ribonucleotide biosynthetic process|
|drug transport|
|response to calcium ion|
|hexose metabolic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|cellular respiration|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|neurotransmitter transport|
|electron transport chain|
|monosaccharide metabolic process|
|ATP metabolic process|
|mitochondrial transport|
|energy derivation by oxidation of organic compounds|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|response to metal ion|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic anion transport|
|carbohydrate metabolic process|
|drug metabolic process|
|response to inorganic substance|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|anion transport|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|calcium ion binding|
|organophosphate metabolic process|
|ion transmembrane transport|
|oxidation-reduction process|
|response to drug|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|ion transport|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11885
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A13 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>