======= SLC25A25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A25
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 25
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114789|114789]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6KCM7|Q6KCM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608745|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. {ECO:0000269|PubMed:15123600}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATP transmembrane transporter activity|
|ATP transport|
|adenine nucleotide transport|
|purine ribonucleotide transport|
|purine nucleotide transport|
|response to food|
|nucleotide transport|
|response to dietary excess|
|adipose tissue development|
|response to activity|
|carbohydrate derivative transport|
|multicellular organism growth|
|organophosphate ester transport|
|drug transport|
|cellular respiration|
|calcium ion transmembrane transport|
|ATP metabolic process|
|connective tissue development|
|energy derivation by oxidation of organic compounds|
|nucleobase-containing compound transport|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|developmental growth|
|growth|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|organic anion transport|
|response to nutrient levels|
|response to extracellular stimulus|
|sensory organ development|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|calcium ion binding|
|cation transport|
|ion transmembrane transport|
|oxidation-reduction process|
|response to drug|
|transmembrane transport|
|ion transport|
|tissue development|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.09|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.95|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.8|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.76|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.75|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.94|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.03|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.525|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16246
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A25 Expression in NALM6 Cells: 4.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>