======= SLC25A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A3
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5250|5250]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q00325|Q00325]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600370|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphate:proton symporter activity|
|inorganic phosphate transmembrane transporter activity|
|phosphate ion transmembrane transport|
|phosphate ion transport|
|integral component of mitochondrial inner membrane|
|inorganic anion transmembrane transport|
|proton transmembrane transport|
|inorganic anion transport|
|protein-containing complex binding|
|anion transmembrane transport|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|mitochondrion|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.75|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.81|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.82|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.91|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.99|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.99|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.02|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.03|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.07|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.14|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.17|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.26|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.29|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp5d|ATP5D]]|0.497|
|[[:human genes:q:qrsl1|QRSL1]]|0.487|
|[[:human genes:n:ndufb9|NDUFB9]]|0.478|
|[[:human genes:n:ndufb11|NDUFB11]]|0.478|
|[[:human genes:s:sco2|SCO2]]|0.476|
|[[:human genes:g:gfm2|GFM2]]|0.475|
|[[:human genes:n:nars2|NARS2]]|0.475|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.475|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.472|
|[[:human genes:m:mrpl45|MRPL45]]|0.472|
|[[:human genes:m:mrpl21|MRPL21]]|0.469|
|[[:human genes:n:ndufa1|NDUFA1]]|0.465|
|[[:human genes:a:atp5a1|ATP5A1]]|0.464|
|[[:human genes:g:gfm1|GFM1]]|0.461|
|[[:human genes:s:selrc1|SELRC1]]|0.461|
|[[:human genes:p:pars2|PARS2]]|0.458|
|[[:human genes:n:nubpl|NUBPL]]|0.455|
|[[:human genes:n:ndufc2|NDUFC2]]|0.455|
|[[:human genes:n:ndufs2|NDUFS2]]|0.453|
|[[:human genes:m:mrps26|MRPS26]]|0.453|
|[[:human genes:a:atp5c1|ATP5C1]]|0.45|
|[[:human genes:n:ndufa2|NDUFA2]]|0.448|
|[[:human genes:d:dap3|DAP3]]|0.445|
|[[:human genes:t:tufm|TUFM]]|0.444|
|[[:human genes:m:mrpl20|MRPL20]]|0.443|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.443|
|[[:human genes:c:cox16|COX16]]|0.443|
|[[:human genes:g:grsf1|GRSF1]]|0.443|
|[[:human genes:a:atp5o|ATP5O]]|0.442|
|[[:human genes:n:ndufa11|NDUFA11]]|0.442|
|[[:human genes:b:bcs1l|BCS1L]]|0.441|
|[[:human genes:a:aars2|AARS2]]|0.441|
|[[:human genes:l:lars2|LARS2]]|0.441|
|[[:human genes:m:mettl17|METTL17]]|0.438|
|[[:human genes:p:pnpt1|PNPT1]]|0.437|
|[[:human genes:m:mrps27|MRPS27]]|0.437|
|[[:human genes:p:pet117|PET117]]|0.437|
|[[:human genes:t:tars2|TARS2]]|0.435|
|[[:human genes:y:yars2|YARS2]]|0.433|
|[[:human genes:w:wbscr16|WBSCR16]]|0.433|
|[[:human genes:m:mrps14|MRPS14]]|0.432|
|[[:human genes:c:chchd1|CHCHD1]]|0.431|
|[[:human genes:m:mrpl43|MRPL43]]|0.43|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.43|
|[[:human genes:d:dars2|DARS2]]|0.428|
|[[:human genes:p:polg2|POLG2]]|0.427|
|[[:human genes:r:rars2|RARS2]]|0.426|
|[[:human genes:m:mtg1|MTG1]]|0.426|
|[[:human genes:h:hars2|HARS2]]|0.423|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.423|
|[[:human genes:m:mterfd1|MTERFD1]]|0.423|
|[[:human genes:a:atp5e|ATP5E]]|0.421|
|[[:human genes:f:ftsj2|FTSJ2]]|0.421|
|[[:human genes:m:mto1|MTO1]]|0.421|
|[[:human genes:c:cox7b|COX7B]]|0.418|
|[[:human genes:v:vars2|VARS2]]|0.418|
|[[:human genes:n:ndufb6|NDUFB6]]|0.418|
|[[:human genes:m:mrps6|MRPS6]]|0.417|
|[[:human genes:m:mrps34|MRPS34]]|0.416|
|[[:human genes:c:cox15|COX15]]|0.415|
|[[:human genes:t:tmem242|TMEM242]]|0.415|
|[[:human genes:a:atp5j2|ATP5J2]]|0.414|
|[[:human genes:d:ddx28|DDX28]]|0.414|
|[[:human genes:m:mrps21|MRPS21]]|0.413|
|[[:human genes:s:slc25a51|SLC25A51]]|0.413|
|[[:human genes:n:ndufb5|NDUFB5]]|0.413|
|[[:human genes:n:ndufb4|NDUFB4]]|0.411|
|[[:human genes:p:pet112|PET112]]|0.411|
|[[:human genes:c:coq6|COQ6]]|0.41|
|[[:human genes:r:rpusd3|RPUSD3]]|0.409|
|[[:human genes:m:mrpl47|MRPL47]]|0.409|
|[[:human genes:n:ndufs8|NDUFS8]]|0.409|
|[[:human genes:n:ndufa8|NDUFA8]]|0.409|
|[[:human genes:a:acad9|ACAD9]]|0.408|
|[[:human genes:e:ears2|EARS2]]|0.407|
|[[:human genes:a:atp5h|ATP5H]]|0.403|
|[[:human genes:r:rbfa|RBFA]]|0.403|
|[[:human genes:m:malsu1|MALSU1]]|0.403|
|[[:human genes:n:ndufa3|NDUFA3]]|0.401|
|[[:human genes:m:mrpl53|MRPL53]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 95/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|2/28|
|bone|2/26|
|breast|5/33|
|central nervous system|4/56|
|cervix|2/4|
|colorectal|4/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|4/21|
|liver|3/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1651
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A3 Expression in NALM6 Cells: 8.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>