======= SLC29A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC29A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 29 member 1 (Augustine blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2030|2030]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99808|Q99808]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC29A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC29A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602193|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Inhibited by dipyridamole and dilazep (anticancer chemotherapeutics drugs).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nucleoside tran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|uridine transport|
|pyrimidine nucleoside transport|
|nucleoside transport|
|nucleoside transmembrane transporter activity|
|nucleoside transmembrane transport|
|neurotransmitter reuptake|
|neurotransmitter uptake|
|carbohydrate derivative transport|
|presynapse|
|neurotransmitter transport|
|basolateral plasma membrane|
|nucleobase-containing compound transport|
|apical plasma membrane|
|regulation of neurotransmitter levels|
|import into cell|
|transmembrane transport|
|integral component of plasma membrane|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-4.4|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-3.81|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-3.57|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.72|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-2.64|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.4|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.3|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.12|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.11|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.06|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-1.94|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.91|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.8|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.75|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.74|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.74|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.78|
|[[:results:exp303|39°C R06 exp303]]|1.84|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|2|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|3.56|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|3.86|
|[[:results:exp211|AICAR 240μM R05 exp211]]|5.11|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|5.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16656
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC29A1 Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>