======= SLC35E1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC35E1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 35 member E1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79939|79939]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96K37|Q96K37]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC35E1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC35E1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620337|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative transporter. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EamA|
|TPT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|antiporter activity|
|transmembrane transporter activity|
|Golgi apparatus|
|transmembrane transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-4.26|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-3.75|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.64|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.58|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.29|
|[[:results:exp539|42°C R08 exp539]]|-1.84|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.83|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.81|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.75|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.7|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.78|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.81|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.16|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|3.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:entpd4|ENTPD4]]|0.469|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15561
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC35E1 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>