======= SLC38A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC38A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 38 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54407|54407]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96QD8|Q96QD8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC38A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC38A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood- brain barrier and in the supply of maternal nutrients to the fetus through the placenta. {ECO:0000269|PubMed:10930503, ECO:0000269|PubMed:15922329}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aa trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycine betaine transport|
|glutamine transport|
|L-glutamine transmembrane transporter activity|
|amino-acid betaine transport|
|alanine transport|
|quaternary ammonium group transport|
|modified amino acid transport|
|glutamate secretion|
|organic cation transport|
|amino acid transmembrane transporter activity|
|neutral amino acid transport|
|symporter activity|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|acidic amino acid transport|
|brush border|
|ammonium transport|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|cellular response to mechanical stimulus|
|acid secretion|
|sarcolemma|
|cerebral cortex development|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|cellular response to starvation|
|sodium ion transport|
|pallium development|
|female pregnancy|
|response to starvation|
|multi-multicellular organism process|
|response to mechanical stimulus|
|cellular response to nutrient levels|
|telencephalon development|
|cellular response to extracellular stimulus|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|axon|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|cellular response to external stimulus|
|neuronal cell body|
|forebrain development|
|monovalent inorganic cation transport|
|dendrite|
|organic anion transport|
|response to nutrient levels|
|response to extracellular stimulus|
|anion transport|
|metal ion transport|
|brain development|
|head development|
|cation transport|
|ion transmembrane transport|
|central nervous system development|
|multi-organism reproductive process|
|secretion by cell|
|export from cell|
|secretion|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|cellular response to stress|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.83|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cul4a|CUL4A]]|0.423|
|[[:human genes:u:ube2g1|UBE2G1]]|0.411|
|[[:human genes:s:slc38a1|SLC38A1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3553
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC38A2 Expression in NALM6 Cells: 8.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>