======= SLC38A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC38A3
  * **<color #00a2e8>Official Name</color>**: solute carrier family 38 member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10991|10991]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99624|Q99624]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC38A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC38A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604437|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. {ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10823827}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aa trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of glutamine transport|
|asparagine transport|
|histidine transport|
|L-asparagine transmembrane transporter activity|
|positive regulation of transcription from RNA polymerase II promoter in response to acidic pH|
|regulation of glutamine transport|
|L-histidine transmembrane transporter activity|
|cellular response to potassium ion starvation|
|L-histidine transmembrane transport|
|L-glutamine transmembrane transporter activity|
|glutamine transport|
|L-alanine transmembrane transporter activity|
|L-alanine transport|
|alanine transport|
|aromatic amino acid transport|
|cellular response to acidic pH|
|basic amino acid transport|
|positive regulation of amino acid transport|
|azole transport|
|cellular response to pH|
|antiporter activity|
|response to acidic pH|
|regulation of amino acid transport|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|neutral amino acid transport|
|amino acid transmembrane transporter activity|
|response to pH|
|symporter activity|
|L-alpha-amino acid transmembrane transport|
|positive regulation of anion transport|
|regulation of organic acid transport|
|L-amino acid transport|
|drug transmembrane transport|
|amino acid transmembrane transport|
|regulation of amine transport|
|regulation of anion transport|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|monocarboxylic acid transport|
|drug transport|
|cellular response to starvation|
|sodium ion transport|
|female pregnancy|
|response to starvation|
|basolateral plasma membrane|
|multi-multicellular organism process|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|positive regulation of ion transport|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|cellular response to external stimulus|
|monovalent inorganic cation transport|
|organic anion transport|
|response to nutrient levels|
|response to extracellular stimulus|
|anion transport|
|cation transmembrane transport|
|metal ion transport|
|regulation of ion transport|
|brain development|
|head development|
|cation transport|
|ion transmembrane transport|
|central nervous system development|
|positive regulation of transport|
|multi-organism reproductive process|
|response to drug|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of transcription, DNA-templated|
|amide transport|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|positive regulation of RNA metabolic process|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.87|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6505
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC38A3 Expression in NALM6 Cells: -1.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>