======= SLC38A7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC38A7
  * **<color #00a2e8>Official Name</color>**: solute carrier family 38 member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55238|55238]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVC3|Q9NVC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC38A7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC38A7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614236|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates sodium-dependent transport of amino acids, preferentially L-glutamine. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Trp Tyr perm|
|Aa trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-methionine transmembrane transporter activity|
|methionine transport|
|L-asparagine transmembrane transporter activity|
|asparagine transport|
|L-leucine transmembrane transporter activity|
|L-histidine transmembrane transporter activity|
|L-histidine transmembrane transport|
|glutamine transport|
|L-serine transport|
|L-glutamine transmembrane transporter activity|
|L-serine transmembrane transporter activity|
|branched-chain amino acid transport|
|L-aspartate transmembrane transporter activity|
|L-alanine transport|
|sulfur amino acid transport|
|L-alanine transmembrane transporter activity|
|serine transport|
|L-aspartate transmembrane transport|
|aromatic amino acid transport|
|alanine transport|
|L-glutamate transmembrane transporter activity|
|L-amino acid transmembrane transporter activity|
|azole transport|
|L-glutamate transmembrane transport|
|C4-dicarboxylate transport|
|amino acid transmembrane transporter activity|
|neutral amino acid transport|
|sulfur compound transport|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|L-amino acid transport|
|drug transmembrane transport|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|monocarboxylic acid transport|
|drug transport|
|sodium ion transport|
|neurotransmitter transport|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|axon|
|neuronal cell body|
|monovalent inorganic cation transport|
|organic anion transport|
|anion transport|
|cation transmembrane transport|
|metal ion transport|
|cation transport|
|ion transmembrane transport|
|response to drug|
|transmembrane transport|
|ion transport|
|amide transport|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.75|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.72|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.71|
|[[:results:exp302|35°C R06 exp302]]|1.72|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.87|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cbwd5|CBWD5]]|0.525|
|[[:human genes:r:rrm1|RRM1]]|0.523|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.515|
|[[:human genes:c:cbwd3|CBWD3]]|0.51|
|[[:human genes:s:ssh2|SSH2]]|0.508|
|[[:human genes:r:rnf121|RNF121]]|0.508|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.497|
|[[:human genes:r:rrp7a|RRP7A]]|0.494|
|[[:human genes:p:psmb4|PSMB4]]|0.493|
|[[:human genes:c:copg1|COPG1]]|0.489|
|[[:human genes:t:tceb3c|TCEB3C]]|0.486|
|[[:human genes:d:ddtl|DDTL]]|0.484|
|[[:human genes:p:pola1|POLA1]]|0.481|
|[[:human genes:c:cbwd6|CBWD6]]|0.481|
|[[:human genes:z:zfand5|ZFAND5]]|0.48|
|[[:human genes:p:psmd3|PSMD3]]|0.477|
|[[:human genes:p:psmb2|PSMB2]]|0.47|
|[[:human genes:p:polr2j3|POLR2J3]]|0.467|
|[[:human genes:s:supt6h|SUPT6H]]|0.466|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.464|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.462|
|[[:human genes:r:rpl35|RPL35]]|0.46|
|[[:human genes:n:nupl1|NUPL1]]|0.46|
|[[:human genes:a:aqr|AQR]]|0.459|
|[[:human genes:c:chd4|CHD4]]|0.458|
|[[:human genes:r:rps2|RPS2]]|0.457|
|[[:human genes:p:pwp2|PWP2]]|0.456|
|[[:human genes:b:bysl|BYSL]]|0.454|
|[[:human genes:p:pan2|PAN2]]|0.453|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.451|
|[[:human genes:p:psma6|PSMA6]]|0.45|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.45|
|[[:human genes:p:psap|PSAP]]|0.448|
|[[:human genes:f:fam25b|FAM25B]]|0.447|
|[[:human genes:m:med14|MED14]]|0.447|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.446|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.446|
|[[:human genes:s:slc6a17|SLC6A17]]|0.443|
|[[:human genes:l:lad1|LAD1]]|0.442|
|[[:human genes:r:rps7|RPS7]]|0.441|
|[[:human genes:u:upf1|UPF1]]|0.44|
|[[:human genes:c:ccna2|CCNA2]]|0.44|
|[[:human genes:p:polr2d|POLR2D]]|0.438|
|[[:human genes:g:golga8j|GOLGA8J]]|0.438|
|[[:human genes:n:nup107|NUP107]]|0.437|
|[[:human genes:m:med17|MED17]]|0.437|
|[[:human genes:p:polr2f|POLR2F]]|0.436|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.436|
|[[:human genes:l:lrr1|LRR1]]|0.435|
|[[:human genes:t:traip|TRAIP]]|0.434|
|[[:human genes:n:nup160|NUP160]]|0.432|
|[[:human genes:s:slc4a1|SLC4A1]]|0.432|
|[[:human genes:a:aatf|AATF]]|0.432|
|[[:human genes:f:fcn2|FCN2]]|0.431|
|[[:human genes:f:fbl|FBL]]|0.431|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.43|
|[[:human genes:r:rnpc3|RNPC3]]|0.428|
|[[:human genes:s:sult1a3|SULT1A3]]|0.426|
|[[:human genes:c:cdc45|CDC45]]|0.426|
|[[:human genes:s:sult1a4|SULT1A4]]|0.426|
|[[:human genes:p:psmd2|PSMD2]]|0.424|
|[[:human genes:p:psmd1|PSMD1]]|0.423|
|[[:human genes:h:hap1|HAP1]]|0.423|
|[[:human genes:s:scaf1|SCAF1]]|0.422|
|[[:human genes:r:rbbp5|RBBP5]]|0.421|
|[[:human genes:n:npipb5|NPIPB5]]|0.421|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.421|
|[[:human genes:c:c14orf93|C14orf93]]|0.418|
|[[:human genes:m:med12|MED12]]|0.418|
|[[:human genes:c:copz1|COPZ1]]|0.417|
|[[:human genes:d:dtl|DTL]]|0.416|
|[[:human genes:a:ahctf1|AHCTF1]]|0.415|
|[[:human genes:p:psmd11|PSMD11]]|0.415|
|[[:human genes:r:riok2|RIOK2]]|0.413|
|[[:human genes:r:rad21|RAD21]]|0.413|
|[[:human genes:s:syt9|SYT9]]|0.413|
|[[:human genes:v:vasn|VASN]]|0.412|
|[[:human genes:r:rpl6|RPL6]]|0.412|
|[[:human genes:e:exosc5|EXOSC5]]|0.411|
|[[:human genes:s:snip1|SNIP1]]|0.411|
|[[:human genes:r:rad51|RAD51]]|0.411|
|[[:human genes:p:pbxip1|PBXIP1]]|0.41|
|[[:human genes:g:golga8k|GOLGA8K]]|0.409|
|[[:human genes:p:psma7|PSMA7]]|0.409|
|[[:human genes:o:orc1|ORC1]]|0.409|
|[[:human genes:a:ankle2|ANKLE2]]|0.409|
|[[:human genes:r:rps12|RPS12]]|0.408|
|[[:human genes:m:mdm2|MDM2]]|0.408|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.407|
|[[:human genes:s:sema6b|SEMA6B]]|0.406|
|[[:human genes:p:polr2l|POLR2L]]|0.406|
|[[:human genes:s:s1pr4|S1PR4]]|0.404|
|[[:human genes:f:fam86b2|FAM86B2]]|0.404|
|[[:human genes:r:rilpl2|RILPL2]]|0.404|
|[[:human genes:p:prpf8|PRPF8]]|0.404|
|[[:human genes:t:tspy8|TSPY8]]|0.404|
|[[:human genes:p:psmd14|PSMD14]]|0.404|
|[[:human genes:p:psmc2|PSMC2]]|0.403|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.403|
|[[:human genes:a:art5|ART5]]|0.403|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.403|
|[[:human genes:r:rrn3|RRN3]]|0.402|
|[[:human genes:v:vps52|VPS52]]|0.401|
|[[:human genes:c:cactin|CACTIN]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2100
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC38A7 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>