======= SLC38A9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC38A9
  * **<color #00a2e8>Official Name</color>**: solute carrier family 38 member 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=153129|153129]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NBW4|Q8NBW4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC38A9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC38A9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616203|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25561175, PubMed:25567906). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids, suggesting that it acts as an amino acid sensor instead (PubMed:25561175, PubMed:25567906). The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor (PubMed:25567906). {ECO:0000269|PubMed:25561175, ECO:0000269|PubMed:25567906}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aa trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-arginine transmembrane transporter activity|
|L-leucine transmembrane transporter activity|
|integral component of lysosomal membrane|
|L-arginine transmembrane transport|
|arginine transmembrane transport|
|branched-chain amino acid transport|
|L-arginine transport|
|Ragulator complex|
|arginine transport|
|basic amino acid transmembrane transport|
|basic amino acid transport|
|amino acid transmembrane transporter activity|
|neutral amino acid transport|
|positive regulation of TOR signaling|
|L-alpha-amino acid transmembrane transport|
|L-amino acid transport|
|cellular response to amino acid stimulus|
|drug transmembrane transport|
|amino acid transmembrane transport|
|regulation of TOR signaling|
|response to amino acid|
|amino acid transport|
|late endosome|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|cell cycle arrest|
|drug transport|
|regulation of macroautophagy|
|cellular response to acid chemical|
|lysosome|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|lysosomal membrane|
|regulation of autophagy|
|response to acid chemical|
|organic anion transport|
|negative regulation of cell cycle|
|anion transport|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|cellular response to nitrogen compound|
|intracellular membrane-bounded organelle|
|cation transport|
|regulation of cellular catabolic process|
|ion transmembrane transport|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|response to drug|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|transmembrane transport|
|cell cycle|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.8|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18137
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC38A9 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>