======= SLC44A4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC44A4
  * **<color #00a2e8>Official Name</color>**: solute carrier family 44 member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80736|80736]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53GD3|Q53GD3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC44A4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC44A4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606107|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) (PubMed:23651124, PubMed:28013291). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota- generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411). {ECO:0000250|UniProtKB:Q7T2B0, ECO:0000269|PubMed:23651124, ECO:0000269|PubMed:24379411, ECO:0000269|PubMed:28013291}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Choline transpo|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetylcholine secretion|
|otolith formation|
|neuromast hair cell differentiation|
|lateral line development|
|acetylcholine transport|
|neuromast development|
|neuromast hair cell development|
|lateral line system development|
|thiamine pyrophosphate transmembrane transporter activity|
|thiamine pyrophosphate transmembrane transport|
|acetate ester biosynthetic process|
|acetylcholine biosynthetic process|
|acetate ester transport|
|otolith morphogenesis|
|choline transmembrane transporter activity|
|acetylcholine metabolic process|
|acetate ester metabolic process|
|choline transport|
|otolith development|
|pyrimidine-containing compound transmembrane transport|
|azole transport|
|organic cation transport|
|hair cell differentiation|
|phosphatidylcholine biosynthetic process|
|neurotransmitter biosynthetic process|
|sulfur compound transport|
|cofactor transport|
|ammonium transport|
|mechanoreceptor differentiation|
|hormone biosynthetic process|
|phosphatidylcholine metabolic process|
|neurotransmitter metabolic process|
|inner ear morphogenesis|
|ear morphogenesis|
|organophosphate ester transport|
|drug transport|
|positive regulation of cell growth|
|neurotransmitter transport|
|inner ear development|
|ammonium ion metabolic process|
|hormone metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|ear development|
|phospholipid biosynthetic process|
|sensory organ morphogenesis|
|positive regulation of growth|
|anion transmembrane transport|
|embryonic organ morphogenesis|
|glycerophospholipid metabolic process|
|epidermal cell differentiation|
|apical plasma membrane|
|regulation of neurotransmitter levels|
|sensory system development|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|epidermis development|
|regulation of cell growth|
|embryonic organ development|
|organic anion transport|
|drug metabolic process|
|regulation of hormone levels|
|organophosphate biosynthetic process|
|sensory organ development|
|embryonic morphogenesis|
|lipid biosynthetic process|
|anion transport|
|cation transmembrane transport|
|regulation of growth|
|epithelial cell differentiation|
|neuron development|
|cation transport|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|ion transmembrane transport|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|embryo development|
|secretion by cell|
|neuron differentiation|
|response to drug|
|export from cell|
|epithelium development|
|secretion|
|lipid metabolic process|
|transmembrane transport|
|ion transport|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|neurogenesis|
|cell development|
|tissue development|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3319
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC44A4 Expression in NALM6 Cells: 2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>