======= SLC4A10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC4A10
  * **<color #00a2e8>Official Name</color>**: solute carrier family 4 member 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57282|57282]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6U841|Q6U841]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC4A10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC4A10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605556|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 3 cyto|
|HCO3 cotransp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CA3 pyramidal cell dendrite|
|sodium:bicarbonate symporter activity|
|basal dendrite|
|pyramidal neuron development|
|pyramidal neuron differentiation|
|somatodendritic compartment|
|inorganic anion exchanger activity|
|locomotory exploration behavior|
|regulation of short-term neuronal synaptic plasticity|
|apical dendrite|
|anion:anion antiporter activity|
|exploration behavior|
|forebrain neuron development|
|brain morphogenesis|
|bicarbonate transport|
|forebrain neuron differentiation|
|axon terminus|
|regulation of neuronal synaptic plasticity|
|forebrain generation of neurons|
|central nervous system neuron development|
|multicellular organism growth|
|regulation of intracellular pH|
|post-embryonic development|
|regulation of cellular pH|
|regulation of pH|
|chloride transport|
|cellular monovalent inorganic cation homeostasis|
|perikaryon|
|monovalent inorganic cation homeostasis|
|proton transmembrane transport|
|sodium ion transport|
|inorganic anion transport|
|central nervous system neuron differentiation|
|regulation of synaptic plasticity|
|locomotory behavior|
|basolateral plasma membrane|
|visual perception|
|sensory perception of light stimulus|
|synapse|
|anion transmembrane transport|
|response to light stimulus|
|apical plasma membrane|
|neuronal cell body|
|forebrain development|
|developmental growth|
|growth|
|monovalent inorganic cation transport|
|dendrite|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|cell junction|
|inorganic cation transmembrane transport|
|behavior|
|anion transport|
|cation transmembrane transport|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|brain development|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|neuron development|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|animal organ morphogenesis|
|sensory perception|
|central nervous system development|
|neuron differentiation|
|chemical homeostasis|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.82|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11588
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC4A10 Expression in NALM6 Cells: -1.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>