======= SLC6A4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC6A4
  * **<color #00a2e8>Official Name</color>**: solute carrier family 6 member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6532|6532]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31645|P31645]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC6A4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC6A4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182138|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. {ECO:0000269|PubMed:17506858, ECO:0000269|PubMed:18227069, ECO:0000269|PubMed:19270731, ECO:0000269|PubMed:27049939}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|5HT transporter|
|SNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cocaine binding|
|regulation of thalamus size|
|positive regulation of serotonin secretion|
|serotonergic synapse|
|negative regulation of cerebellar granule cell precursor proliferation|
|serotonin:sodium symporter activity|
|serotonin uptake|
|negative regulation of synaptic transmission, dopaminergic|
|sperm ejaculation|
|cellular response to cGMP|
|monoamine transmembrane transporter activity|
|serotonin transport|
|regulation of serotonin secretion|
|response to cGMP|
|serotonin binding|
|regulation of cerebellar granule cell precursor proliferation|
|insemination|
|nitric-oxide synthase binding|
|copulation|
|neurotransmitter reuptake|
|regulation of synaptic transmission, dopaminergic|
|monoamine transport|
|negative regulation of neural precursor cell proliferation|
|myosin binding|
|syntaxin-1 binding|
|neurotransmitter uptake|
|vasoconstriction|
|negative regulation of organ growth|
|brain morphogenesis|
|mating|
|positive regulation of neurotransmitter transport|
|negative regulation of blood vessel diameter|
|neurotransmitter biosynthetic process|
|integral component of postsynaptic membrane|
|ammonium transport|
|intraspecies interaction between organisms|
|social behavior|
|integral component of presynaptic membrane|
|negative regulation of synaptic transmission|
|multi-organism behavior|
|cellular response to retinoic acid|
|endomembrane system|
|regulation of neural precursor cell proliferation|
|neurotransmitter metabolic process|
|regulation of organ growth|
|negative regulation of developmental growth|
|response to retinoic acid|
|memory|
|response to organophosphorus|
|response to estradiol|
|organic hydroxy compound transport|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|circadian rhythm|
|regulation of neurotransmitter transport|
|Rab GTPase binding|
|response to purine-containing compound|
|vascular process in circulatory system|
|neurotransmitter transport|
|actin filament binding|
|cellular response to acid chemical|
|multi-multicellular organism process|
|endosome membrane|
|response to nutrient|
|negative regulation of neuron differentiation|
|membrane raft|
|negative regulation of growth|
|learning or memory|
|synapse|
|positive regulation of ion transport|
|rhythmic process|
|negative regulation of neurogenesis|
|cognition|
|negative regulation of nervous system development|
|neuron projection|
|regulation of developmental growth|
|negative regulation of cell development|
|protein homooligomerization|
|response to hypoxia|
|response to acid chemical|
|regulation of neurotransmitter levels|
|response to decreased oxygen levels|
|positive regulation of cell cycle|
|response to oxygen levels|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|focal adhesion|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|response to nutrient levels|
|response to toxic substance|
|regulation of anatomical structure size|
|protein complex oligomerization|
|cellular response to lipid|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|behavior|
|cellular response to organonitrogen compound|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of growth|
|import into cell|
|negative regulation of cell population proliferation|
|regulation of ion transport|
|negative regulation of cell differentiation|
|brain development|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|cation transport|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|protein homodimerization activity|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|central nervous system development|
|positive regulation of transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|nervous system process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|neurogenesis|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5315
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC6A4 Expression in NALM6 Cells: 3.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>