======= SLC7A11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC7A11
  * **<color #00a2e8>Official Name</color>**: solute carrier family 7 member 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23657|23657]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPY5|Q9UPY5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC7A11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC7A11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607933|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. {ECO:0000269|PubMed:15151999}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AA permease|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cysteine metabolic process|
|oligopeptide import across plasma membrane|
|dipeptide import across plasma membrane|
|cystine:glutamate antiporter activity|
|tripeptide transmembrane transport|
|regulation of glutathione biosynthetic process|
|glutathione transmembrane transport|
|dipeptide transmembrane transport|
|dipeptide transport|
|regulation of sulfur amino acid metabolic process|
|tripeptide transport|
|glutathione transport|
|regulation of glutamate metabolic process|
|glutamate homeostasis|
|regulation of glutamate receptor clustering|
|amino acid homeostasis|
|regulation of AMPA glutamate receptor clustering|
|regulation of glutamine family amino acid metabolic process|
|regulation of neutrophil apoptotic process|
|astrocyte projection|
|L-glutamate import across plasma membrane|
|oligopeptide transmembrane transport|
|oligopeptide transport|
|L-glutamate import|
|regulation of melanin biosynthetic process|
|regulation of secondary metabolite biosynthetic process|
|regulation of receptor clustering|
|regulation of secondary metabolic process|
|response to redox state|
|regulation of postsynaptic membrane organization|
|L-amino acid transmembrane transporter activity|
|regulation of sulfur metabolic process|
|amino acid import across plasma membrane|
|striatum development|
|L-glutamate transmembrane transport|
|negative regulation of oxidative stress-induced neuron death|
|amino acid import|
|subpallium development|
|modified amino acid transport|
|regulation of oxidative stress-induced neuron death|
|ventricular system development|
|lens fiber cell differentiation|
|regulation of myeloid cell apoptotic process|
|neurotransmitter uptake|
|regulation of cofactor metabolic process|
|lung alveolus development|
|platelet aggregation|
|sulfur compound transport|
|negative regulation of oxidative stress-induced cell death|
|negative regulation of cellular response to oxidative stress|
|cofactor transport|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|negative regulation of response to oxidative stress|
|visual learning|
|response to nicotine|
|brush border membrane|
|visual behavior|
|glutathione metabolic process|
|anion homeostasis|
|L-amino acid transport|
|homotypic cell-cell adhesion|
|rough endoplasmic reticulum|
|regulation of cellular amino acid metabolic process|
|regulation of oxidative stress-induced cell death|
|drug transmembrane transport|
|regulation of cellular response to oxidative stress|
|amino acid transmembrane transport|
|lens development in camera-type eye|
|associative learning|
|dicarboxylic acid transport|
|regulation of cellular amine metabolic process|
|regulation of leukocyte apoptotic process|
|regulation of response to oxidative stress|
|regulation of postsynapse organization|
|import across plasma membrane|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|platelet activation|
|adult behavior|
|learning|
|drug transport|
|lung development|
|regulation of cellular ketone metabolic process|
|respiratory tube development|
|neurotransmitter transport|
|appendage development|
|limb development|
|regulation of protein localization to membrane|
|respiratory system development|
|cellular modified amino acid metabolic process|
|negative regulation of neuron death|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|cellular response to oxidative stress|
|telencephalon development|
|learning or memory|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|blood coagulation|
|coagulation|
|hemostasis|
|cognition|
|response to light stimulus|
|regulation of neuron death|
|camera-type eye development|
|regulation of neurotransmitter levels|
|eye development|
|visual system development|
|cytoskeleton|
|sulfur compound metabolic process|
|sensory system development|
|leukocyte migration|
|response to oxidative stress|
|forebrain development|
|regulation of cellular amide metabolic process|
|regulation of small molecule metabolic process|
|cofactor metabolic process|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|wound healing|
|regulation of body fluid levels|
|cell-cell adhesion|
|response to toxic substance|
|peptide metabolic process|
|regulation of cellular protein localization|
|sensory organ development|
|behavior|
|response to wounding|
|anion transport|
|cell surface|
|import into cell|
|epithelial cell differentiation|
|regulation of protein transport|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|head development|
|cellular amide metabolic process|
|ion homeostasis|
|tube development|
|regulation of cellular localization|
|response to organic cyclic compound|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|cell migration|
|central nervous system development|
|negative regulation of cell death|
|response to drug|
|regulation of protein localization|
|cell activation|
|localization of cell|
|cell motility|
|chemical homeostasis|
|epithelium development|
|response to abiotic stimulus|
|transmembrane transport|
|locomotion|
|ion transport|
|nervous system process|
|regulation of response to stress|
|peptide transport|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|tissue development|
|nitrogen compound transport|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp292|Menadione 5μM R06 exp292]]|-5.18|
|[[:results:exp340|BN82002 4μM R07 exp340]]|-3.3|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-3.17|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.79|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.63|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.58|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.49|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.31|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.16|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2.03|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-2.02|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.84|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.83|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.8|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.79|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.79|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.74|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.04|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gclm|GCLM]]|0.428|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13008
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC7A11 Expression in NALM6 Cells: 4.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>