======= SMAD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMAD1
  * **<color #00a2e8>Official Name</color>**: SMAD family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4086|4086]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15797|Q15797]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMAD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMAD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601595|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. {ECO:0000269|PubMed:12097147}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRF-3|
|MH1|
|MH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|osteoblast fate commitment|
|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|
|SMAD protein complex assembly|
|SMAD protein complex|
|primary miRNA binding|
|DEAD/H-box RNA helicase binding|
|primary miRNA processing|
|I-SMAD binding|
|co-SMAD binding|
|mesodermal cell fate commitment|
|cardiac muscle cell proliferation|
|striated muscle cell proliferation|
|muscle cell proliferation|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|mesodermal cell differentiation|
|cardiac muscle tissue growth|
|cell fate commitment involved in formation of primary germ layer|
|heart growth|
|production of miRNAs involved in gene silencing by miRNA|
|positive regulation of pri-miRNA transcription by RNA polymerase II|
|positive regulation of cartilage development|
|dsRNA processing|
|production of small RNA involved in gene silencing by RNA|
|positive regulation of sprouting angiogenesis|
|regulation of pri-miRNA transcription by RNA polymerase II|
|nuclear inner membrane|
|gene silencing by miRNA|
|SMAD protein signal transduction|
|posttranscriptional gene silencing by RNA|
|positive regulation of osteoblast differentiation|
|posttranscriptional gene silencing|
|embryonic pattern specification|
|mesoderm formation|
|regulation of sprouting angiogenesis|
|mesoderm morphogenesis|
|regulation of cartilage development|
|positive regulation of ossification|
|ureteric bud development|
|midbrain development|
|mesonephric epithelium development|
|mesonephric tubule development|
|gene silencing by RNA|
|BMP signaling pathway|
|mesonephros development|
|organ growth|
|transforming growth factor beta receptor signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|formation of primary germ layer|
|regulation of osteoblast differentiation|
|mesoderm development|
|osteoblast differentiation|
|kidney epithelium development|
|hindbrain development|
|gene silencing|
|cellular response to transforming growth factor beta stimulus|
|gastrulation|
|response to transforming growth factor beta|
|cardiac muscle tissue development|
|positive regulation of angiogenesis|
|cartilage development|
|positive regulation of vasculature development|
|regulation of ossification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|transcription factor complex|
|connective tissue development|
|regulation of gene expression, epigenetic|
|cell fate commitment|
|ossification|
|kidney development|
|protein deubiquitination|
|striated muscle tissue development|
|renal system development|
|regulation of angiogenesis|
|muscle tissue development|
|protein modification by small protein removal|
|urogenital system development|
|regulation of vasculature development|
|MAPK cascade|
|ncRNA processing|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|protein kinase binding|
|ncRNA metabolic process|
|protein heterodimerization activity|
|skeletal system development|
|inflammatory response|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|posttranscriptional regulation of gene expression|
|heart development|
|response to growth factor|
|cellular response to organic cyclic compound|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|protein-containing complex|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|brain development|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|tube development|
|circulatory system development|
|RNA processing|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|epithelium development|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|proteolysis|
|phosphorylation|
|defense response|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13600
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMAD1 Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>