======= SMAD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMAD5
  * **<color #00a2e8>Official Name</color>**: SMAD family member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4090|4090]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99717|Q99717]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMAD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMAD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603110|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IRF-3|
|MH1|
|MH2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Mullerian duct regression|
|osteoblast fate commitment|
|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|
|SMAD protein complex|
|DEAD/H-box RNA helicase binding|
|anatomical structure regression|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|SMAD protein signal transduction|
|positive regulation of osteoblast differentiation|
|embryonic pattern specification|
|cardiac muscle contraction|
|erythrocyte differentiation|
|positive regulation of ossification|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|heart contraction|
|erythrocyte homeostasis|
|BMP signaling pathway|
|mesonephros development|
|heart process|
|transforming growth factor beta receptor signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|myeloid cell homeostasis|
|striated muscle contraction|
|regulation of osteoblast differentiation|
|osteoblast differentiation|
|kidney epithelium development|
|cellular response to transforming growth factor beta stimulus|
|male sex differentiation|
|response to transforming growth factor beta|
|cartilage development|
|regulation of ossification|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|homeostasis of number of cells|
|bone development|
|transcription factor complex|
|myeloid cell differentiation|
|connective tissue development|
|cell fate commitment|
|muscle contraction|
|germ cell development|
|ossification|
|sex differentiation|
|kidney development|
|renal system development|
|ubiquitin protein ligase binding|
|muscle system process|
|urogenital system development|
|cellular process involved in reproduction in multicellular organism|
|blood circulation|
|circulatory system process|
|pattern specification process|
|skeletal system development|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to growth factor|
|cellular response to organic cyclic compound|
|hemopoiesis|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|immune system development|
|developmental process involved in reproduction|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|multi-organism reproductive process|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.14|
|[[:results:exp539|42°C R08 exp539]]|-1.78|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.76|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15708
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMAD5 Expression in NALM6 Cells: 6.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>