======= SMAD9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMAD9
  * **<color #00a2e8>Official Name</color>**: SMAD family member 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4093|4093]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15198|O15198]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMAD9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMAD9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MH2|
|IRF-3|
|MH1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|
|SMAD protein complex|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|SMAD protein signal transduction|
|intracellular|
|BMP signaling pathway|
|transforming growth factor beta receptor signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|transcription factor complex|
|cellular response to growth factor stimulus|
|response to growth factor|
|enzyme linked receptor protein signaling pathway|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|DNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.28|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.01|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.94|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.94|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.9|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.87|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.85|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.78|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.72|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.79|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9972
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMAD9 Expression in NALM6 Cells: 3.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>