======= SMARCD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SMARCD1
  * **<color #00a2e8>Official Name</color>**: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6602|6602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96GM5|Q96GM5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SMARCD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SMARCD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601735|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342). {ECO:0000250|UniProtKB:Q61466, ECO:0000269|PubMed:12917342, ECO:0000269|PubMed:14698202, ECO:0000269|PubMed:8804307, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SWIB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromatin-mediated maintenance of transcription|
|npBAF complex|
|nBAF complex|
|nucleosome disassembly|
|chromatin disassembly|
|SWI/SNF complex|
|protein-DNA complex disassembly|
|molecular adaptor activity|
|cellular response to fatty acid|
|positive regulation of gene expression, epigenetic|
|chromatin organization involved in regulation of transcription|
|response to fatty acid|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|cellular response to acid chemical|
|regulation of gene expression, epigenetic|
|protein-containing complex disassembly|
|protein-DNA complex subunit organization|
|transcription coactivator activity|
|signaling receptor binding|
|response to acid chemical|
|chromatin binding|
|cellular component disassembly|
|cellular response to lipid|
|intracellular membrane-bounded organelle|
|chromatin organization|
|response to lipid|
|cellular response to oxygen-containing compound|
|chromosome organization|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:seh1l|SEH1L]]|0.482|
|[[:human genes:b:bcl7a|BCL7A]]|0.471|
|[[:human genes:m:max|MAX]]|0.466|
|[[:human genes:c:ccdc101|CCDC101]]|0.45|
|[[:human genes:m:meaf6|MEAF6]]|0.448|
|[[:human genes:u:ube3a|UBE3A]]|0.446|
|[[:human genes:h:hars|HARS]]|0.444|
|[[:human genes:s:slc35b1|SLC35B1]]|0.444|
|[[:human genes:r:rptor|RPTOR]]|0.442|
|[[:human genes:a:aars|AARS]]|0.44|
|[[:human genes:t:tada1|TADA1]]|0.439|
|[[:human genes:c:cars|CARS]]|0.437|
|[[:human genes:m:med23|MED23]]|0.433|
|[[:human genes:t:tada3|TADA3]]|0.425|
|[[:human genes:t:tti2|TTI2]]|0.423|
|[[:human genes:m:mtor|MTOR]]|0.422|
|[[:human genes:c:csnk2b|CSNK2B]]|0.419|
|[[:human genes:g:gltscr1l|GLTSCR1L]]|0.418|
|[[:human genes:s:supt20h|SUPT20H]]|0.41|
|[[:human genes:r:runx1|RUNX1]]|0.408|
|[[:human genes:m:med16|MED16]]|0.407|
|[[:human genes:t:tti1|TTI1]]|0.406|
|[[:human genes:w:wdr24|WDR24]]|0.404|
|[[:human genes:m:mllt1|MLLT1]]|0.402|
|[[:human genes:r:rnmt|RNMT]]|0.401|
|[[:human genes:n:naa35|NAA35]]|0.401|
|[[:human genes:l:lsmd1|LSMD1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1424
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SMARCD1 Expression in NALM6 Cells: 7.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>